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In Vitro and In Vivo Detection of Mitophagy in Human Cells, C. Elegans, and Mice
08:40

In Vitro and In Vivo Detection of Mitophagy in Human Cells, C. Elegans, and Mice

Published on: November 22, 2017

17.8K

Mitophagy in carcinogenesis and cancer treatment

Tatiana V Denisenko1, Vladimir Gogvadze1,2, Boris Zhivotovsky3,4

  • 1MV Lomonosov Moscow State University, 119991, Moscow, Russia.

Discover Oncology
|February 24, 2022
PubMed

Insights

Mitophagy, a cellular quality control process, is crucial for mitochondrial health. This review explores mitophagy pathways, including PINK1/Parkin and receptor-mediated mitophagy, and their roles in cancer.

Area of Science:

  • Cell Biology
  • Molecular Biology
  • Oncology

Background:

  • Cells utilize mitophagy for mitochondrial quality control to maintain a functional mitochondrial network.
  • Mitophagy is essential for cellular homeostasis and can be triggered via distinct pathways.
  • Dysregulation of mitophagy is increasingly implicated in various disease states, including cancer.

Purpose of the Study:

  • To summarize current knowledge on mitophagy regulation mechanisms.
  • To elucidate the interplay between mitophagy and cancer progression.
  • To review the role of mitophagy in anticancer treatment efficacy.

Main Methods:

  • Literature review of mitophagy pathways, including PINK1/Parkin and receptor-mediated mitophagy (BNIP3, Nix).
  • Analysis of studies investigating mitophagy's role in cancer development and progression.
  • Examination of research on mitophagy modulation in cancer therapy.

Main Results:

  • The PINK1/Parkin pathway involves ubiquitylation of mitochondrial proteins linked to Parkinson's disease.
  • Receptor-mediated mitophagy utilizes proteins like BNIP3 and Nix.
  • Both pathways are critical for maintaining cellular homeostasis through mitophagy.

Conclusions:

  • Understanding mitophagy mechanisms is key to comprehending cellular health.
  • Mitophagy plays a significant role in cancer progression and response to treatment.
  • Targeting mitophagy pathways may offer novel therapeutic strategies for cancer.
Keywords:
AutophagyCancerHomeostasisMitophagy

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