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Updated: Oct 2, 2025
07:11
Establishment and Validation of a Rat Model of Pulmonary Arterial Hypertension Associated with Pulmonary Fibrosis
Published on: May 23, 2025
404
Physiologically variable ventilation prevents lung function deterioration in a model of pulmonary fibrosis
André Dos Santos Rocha1, Ferenc Peták2, Tânia Carvalho3
1Unit for Anaesthesiological Investigations, Department of Acute Medicine, University Hospitals of Geneva and University of Geneva, Geneva, Switzerland.
Journal of Applied Physiology (Bethesda, Md. : 1985)
|February 24, 2022
Summary
Physiologically variable ventilation (PVV) prevents lung injury in a pulmonary fibrosis model. This approach reduces atelectasis and improves gas exchange compared to conventional pressure-controlled ventilation (PCV).
Area of Science:
- Pulmonary Medicine
- Respiratory Physiology
- Critical Care
Background:
- Positive pressure ventilation increases stress in pulmonary fibrosis, necessitating lung-protective strategies.
- Physiologically variable ventilation (PVV) benefits other lung diseases, but its efficacy in pulmonary fibrosis is unknown.
Purpose of the Study:
- To evaluate the benefits of PVV compared to conventional pressure-controlled ventilation (PCV) in a rabbit model of pulmonary fibrosis.
Main Methods:
- Pulmonary fibrosis was induced using intratracheal bleomycin in rabbits.
- Animals received 6 hours of either PCV or PVV (recorded from healthy rabbits).
- Respiratory mechanics, gas exchange, end-expiratory lung volume, and shunt fraction were assessed.
Main Results:
- PVV significantly reduced increases in tissue damping and elastance compared to PCV.
- PVV attenuated the decrease in end-expiratory lung volume and improved oxygenation.
- PVV prevented atelectasis development, unlike PCV, with no significant difference in histopathology.
Conclusions:
- Prolonged PVV application in bleomycin-induced lung fibrosis prevents gas exchange deterioration.
- PVV reduces atelectasis and improves lung mechanics and ventilation homogeneity.
- PVV represents a promising ventilation strategy for pulmonary fibrosis patients.
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