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Related Experiment Video

Updated: Oct 2, 2025

Implantation and Control of Wireless, Battery-free Systems for Peripheral Nerve Interfacing
07:13

Implantation and Control of Wireless, Battery-free Systems for Peripheral Nerve Interfacing

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A Highly Miniaturized, Chronically Implanted ASIC for Electrical Nerve Stimulation.

Jay Shah, Christopher Quinkert, Brett Collar

    IEEE Transactions on Biomedical Circuits and Systems
    |February 24, 2022
    PubMed
    Summary
    This summary is machine-generated.

    We developed a tiny, wireless implant for peripheral nerve stimulation. This device is biocompatible, fully implantable, and offers adjustable parameters for chronic use in animal models.

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    Last Updated: Oct 2, 2025

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    Area of Science:

    • Biomedical Engineering
    • Neuroscience
    • Implantable Devices

    Background:

    • Peripheral nerve stimulation (PNS) is crucial for treating various neurological conditions.
    • Existing PNS systems often face challenges with wireless power transfer and miniaturization.
    • The need for small, efficient, and long-term implantable stimulators is critical for clinical translation.

    Purpose of the Study:

    • To present a novel wireless, fully implantable device for electrical stimulation of peripheral nerves.
    • To demonstrate the feasibility of a miniaturized, biocompatible stimulator IC for chronic implantation.
    • To evaluate the long-term efficacy and performance of the developed system in a rodent model.

    Main Methods:

    • Designed and fabricated a wireless, implantable device featuring a powering coil, tuning network, Zener diode, and a custom stimulator IC.
    • Utilized a 13.56 MHz RF signal for wireless power transfer and an on-chip rectifier.
    • Developed a miniaturized ASIC (1.2 mm²) enabling externally selectable, current-controlled stimulation with 32 parameter settings.
    • Performed benchtop, acute, and chronic implantation studies in rats, testing both leaded and leadless device versions.

    Main Results:

    • The stimulator IC, measuring less than 1.2 mm², supports 32 stimulation parameters (90-750 µA amplitude, 100 µs/1 ms pulse width, 15/50 Hz frequency).
    • Achieved an average power consumption of 2.6 mW at the highest stimulation setting with ~5.2% power transfer efficiency.
    • Chronic implantation of both leaded and leadless devices in rats demonstrated successful function for 21-90 days.
    • The fabricated IC represents the smallest constant-current stimulator tested chronically to date.

    Conclusions:

    • The developed wireless, implantable device is a promising solution for long-term peripheral nerve stimulation.
    • The miniaturized ASIC and efficient wireless power transfer enable robust, adjustable neural stimulation.
    • Successful chronic implantation in rats validates the system's biocompatibility and long-term efficacy for future therapeutic applications.