Assay of clobazam in human serum by a radioreceptor technique

1 Clobazam has been assayed in human serum using a radioreceptor technique. 2 The assay is simple and sufficiently sensitive for detecting serum levels up to 48 h after oral administration of a usual clinical dose. It has the advantage of measuring the parent compound plus active metabolites. 3 Serum clearances and elimination half-lives have been determined for five subjects.