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Treatment with Pulsed Extremely Low Frequency Electromagnetic Field (PELF-EMF) Exhibit Anti-Inflammatory and
Yona Goldshmit1,2, Moshe Shalom1, Angela Ruban1,3
1Steyer School of Health Professions, Sackler Faculty of Medicine, Tel-Aviv University, Tel Aviv 6997801, Israel.
Biomedicines
|February 25, 2022
Summary
Pulsed electromagnetic fields (PELF-EMF) therapy using the SEQEX device reduced inflammation and protected neurons after spinal cord injury (SCI) in mice. This safe therapy shows promise for treating SCI.
Area of Science:
- Neuroscience
- Regenerative Medicine
- Biomedical Engineering
Background:
- Spinal cord injury (SCI) involves primary trauma and secondary progressive neuroinflammation, excitotoxicity, and degeneration.
- Current treatments for SCI lack effective neuroprotective strategies.
- Pulsed, extremely low-frequency electromagnetic fields (PELF-EMF) show potential therapeutic benefits for neurotrauma.
Purpose of the Study:
- To evaluate the efficacy of the PELF-EMF SEQEX device in a mouse model of compression-induced SCI.
Main Methods:
- C57BL/6 mice received daily 4-hour PELF-EMF treatments for two months, starting 2 hours post-SCI.
- The study utilized a compression-induced SCI model in mice.
Main Results:
- PELF-EMF treatment significantly reduced inflammatory cell infiltration and astrocyte activation (Iba1, F4/80, CD68+, GAFP).
- The therapy increased pro-survival signals like BDNF in neurons and reduced white matter demyelination at the lesion center.
- SEQEX treatment demonstrated significant anti-inflammatory and neuroprotective effects.
Conclusions:
- The SEQEX device, delivering PELF-EMF, exhibited significant anti-inflammatory and neuroprotective effects in a mouse SCI model.
- This safe, commercially available rehabilitative device may offer a valuable therapeutic option for SCI treatment.
