Related Experiment Video
Updated: Oct 2, 2025
09:50
Author Spotlight: Eco-friendly Photoluminescent Textile Authentication with Curcumin
Published on: December 22, 2023
1.9K
Curcumin: Biological Activities and Modern Pharmaceutical Forms
Maja Urošević1, Ljubiša Nikolić1, Ivana Gajić1
1Faculty of Technology, University of Niš, Bulevar Oslobođenja 124, 16000 Leskovac, Serbia.
Antibiotics (Basel, Switzerland)
|February 25, 2022
Summary
Curcumin, a natural polyphenol, shows promise for various health benefits but suffers from poor bioavailability. This review explores methods to improve curcumin
Area of Science:
- Pharmacology and Pharmaceutical Sciences
- Natural Product Chemistry
Background:
- Curcumin (1,7-bis-(4-hydroxy-3-methoxyphenyl)-hepta-1,6-diene-3,5-dione) is a lipophilic polyphenol with diverse pharmacological effects, including anti-inflammatory, antioxidative, and wound-healing properties.
- Despite its therapeutic potential, curcumin exhibits poor bioavailability in humans due to limited absorption, rapid metabolism, and quick systemic elimination.
- Various curcumin formulations have been developed to address these bioavailability challenges.
Purpose of the Study:
- To provide a comprehensive overview of recent advancements in the biological and pharmaceutical aspects of curcumin.
- To review methods for curcumin isolation, identification, and quantification.
- To discuss techniques for developing improved curcumin formulations.
Main Methods:
- Sample preparation techniques reviewed include Soxhlet extraction, ultrasound extraction, pressurized fluid extraction, microwave extraction, and enzyme-assisted extraction.
- Analytical methods for curcumin identification and quantification encompass FTIR, NIR, FT-Raman, UV-VIS, NMR, XRD, DSC, TLC, HPLC, HPTLC, LC-MS, and UPLC/Q-TOF-MS.
- Formulation development techniques are also discussed.
Main Results:
- The paper synthesizes current research on curcumin's pharmacological activities and formulation strategies.
- It highlights various extraction and analytical techniques crucial for accurate curcumin assessment.
- The importance of optimizing sample preparation and analytical methods for evaluating curcumin formulations and biological activity is emphasized.
Conclusions:
- Effective sample preparation and appropriate analytical methods are essential for accurate evaluation of curcumin formulations.
- Improving curcumin bioavailability through advanced formulations is key to unlocking its full therapeutic potential.
- This review serves as a valuable resource for researchers working on curcumin's biological and pharmaceutical applications.
More Related Videos
06:39Author Spotlight: Exploring Photodynamic Therapy with Curcumin in a Murine Model for Oral Candidiasis
Published on: October 27, 2023
1.1K
11:44Cellular Membrane Affinity Chromatography Columns to Identify Specialized Plant Metabolites Interacting with Immobilized Tropomyosin Kinase Receptor B
Published on: January 19, 2022
2.6K
Related Concept Videos
01:28Biopharmaceutics and Pharmacokinetics: Overview
2.7K
Understanding drugs, drug products, and their performance in pharmaceutical science is pivotal. Drugs, whether simple molecules or complex compounds, are designed to interact with the body's biological systems to diagnose, treat, or prevent diseases. Drug products include various delivery systems such as tablets, capsules, injections, and inhalers. The performance of these drug products is gauged by their ability to deliver the active ingredient to the desired site of action at the...
2.7K
01:16Drug Biotransformation: Overview
3.0K
Pharmaceutical substances known as xenobiotics are predominantly lipophilic and nonionized. This enables them to permeate lipid bilayers, such as cell membranes, and interact with intracellular target receptors. Lipophilic drugs have an advantage in crossing biological barriers and reaching their intended sites of action. However, lipophilic drugs often have a restricted capacity for renal expulsion or elimination from the body. When these drugs enter the kidneys and undergo glomerular...
3.0K
01:29Microorganisms in Medicine and Therapeutics
443
Microorganisms play a fundamental role in vaccine development, gene therapy, and therapeutic production. Their biological properties are harnessed to advance medicine and public health. Beyond immunization, microorganisms contribute to gut health, antibiotic synthesis, and genetic disease treatment.Live Attenuated and Inactivated VaccinesLive attenuated vaccines, such as the measles, mumps, and rubella (MMR) vaccine, utilize weakened forms of pathogens to closely resemble natural infections.
443
01:24Principles of Drug Action
6.9K
Drugs are chemical substances that modify biological responses by interacting with macromolecular targets such as receptors, ion channels, transporters, and enzymes. Pharmacodynamics describes the course of action of drugs leading to the physiological effect at a specific site in the body.
Drugs can be agonists or antagonists. Like the endogenous ligands, agonists always bind and activate the target to produce a cellular response. Agonist binding induces a conformational change which in turn...
Drugs can be agonists or antagonists. Like the endogenous ligands, agonists always bind and activate the target to produce a cellular response. Agonist binding induces a conformational change which in turn...
6.9K
01:19Factors Affecting Drug Biotransformation: Biological
283
Biological factors significantly impact drug metabolism, influencing drug clearance, efficacy, and potential toxicity.
Species differences: Variations in enzyme systems across species can cause disparities in drug metabolism. For instance, humans may metabolize certain drugs faster than rodents, altering therapeutic effects.
Strain differences: Genetic variations within a species can result in differing enzyme activity, impacting drug response and toxicity. For example, some mouse strains may...
Species differences: Variations in enzyme systems across species can cause disparities in drug metabolism. For instance, humans may metabolize certain drugs faster than rodents, altering therapeutic effects.
Strain differences: Genetic variations within a species can result in differing enzyme activity, impacting drug response and toxicity. For example, some mouse strains may...
283
01:28Structure-Activity Relationships and Drug Design
1.1K
Drug design is a dynamic field that involves discovering and developing new medications based on specific biological targets. This process heavily relies on structure-activity relationships (SAR) and quantitative structure-activity relationships (QSAR) to guide the design and optimization of efficient drugs.
SAR studies the intricate relationship between a drug's chemical structure and biological activity. It focuses on understanding how modifications to a drug's structure can influence...
SAR studies the intricate relationship between a drug's chemical structure and biological activity. It focuses on understanding how modifications to a drug's structure can influence...
1.1K