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Related Concept Videos

Lipid Absorption01:24

Lipid Absorption

992
Dietary triglycerides from chyme in the duodenum are mixed with bile salts produced by the liver to emulsify fats. As a result, large droplets are broken down into smaller ones, increasing the surface area for enzymatic action. Once emulsified, pancreatic lipases hydrolyze the triglycerides into free fatty acids and monoglycerides.
These breakdown products bind with bile salts and lecithin to form micelles, which quickly pass between microvilli to come in close contact with the apical...
992

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Facile Preparation of Internally Self-assembled Lipid Particles Stabilized by Carbon Nanotubes
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Lipid Nanostructures for Antioxidant Delivery.

Elisabetta Esposito1

  • 1Department of Chemical, Pharmaceutical and Agricultural Sciences, University of Ferrara, Via Fossato di Mortara, 19-44121 Ferrara, Italy.

Antioxidants (Basel, Switzerland)
|February 25, 2022
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Summary

Lipid-based nanosystems show great promise for pharmaceutical applications. These advanced drug delivery systems offer enhanced therapeutic efficacy and targeted delivery for various treatments.

Area of Science:

  • Pharmaceutical Nanotechnology
  • Drug Delivery Systems
  • Biomedical Engineering

Background:

  • Lipid-based nanosystems are increasingly recognized for their versatility in drug formulation.
  • Recent advancements highlight their potential to overcome challenges in drug delivery.
  • These systems offer tunable properties for specific therapeutic needs.

Discussion:

  • The review explores the design principles and fabrication methods of lipid-based nanosystems.
  • It examines their application in delivering various therapeutic agents, including small molecules, proteins, and nucleic acids.
  • Challenges such as stability, scalability, and regulatory approval are also discussed.

Key Insights:

  • Lipid-based nanosystems provide a robust platform for enhancing drug solubility, bioavailability, and targeted delivery.

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  • Their biocompatibility and biodegradability make them attractive for in vivo applications.
  • Successful preclinical and clinical studies underscore their therapeutic potential.

    • Outlook:

    • Future research will focus on optimizing nanosystem design for improved pharmacokinetics and reduced toxicity.
    • Exploration of novel lipid compositions and functionalization strategies will expand their therapeutic scope.
    • Clinical translation and commercialization of lipid-based nanosystems are anticipated in the near future.