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Updated: Oct 2, 2025

A Preterm Rat Model for Pain Studies
Published on: February 9, 2024
Assessment and Management of Pain in Preterm Infants: A Practice Update
Marsha Campbell-Yeo1,2,3, Mats Eriksson4, Britney Benoit5
1School of Nursing, Faculty of Health, Dalhousie University, Halifax, NS B3H 4R2, Canada.
Insights
Preterm infants often experience untreated pain, despite available interventions. Greater parental involvement is crucial for effective pain management in these vulnerable infants.
Area of Science:
- Neonatal care
- Pediatric pain management
- Infant development
Background:
- Preterm infants face significant risks of repeated pain exposure.
- Existing pain assessment tools and interventions are underutilized in this population.
- Parental involvement in pain relief for preterm infants is often overlooked.
Purpose of the Study:
- To review the consequences of untreated pain in preterm infants.
- To recommend standardized pain assessment and effective interventions.
- To advocate for increased parental engagement in infant pain care.
Main Methods:
- This study is a narrative review.
- It synthesizes current literature on pain in preterm infants.
- It covers pain consequences, assessment, interventions, and parental roles.
Main Results:
- Untreated pain has severe consequences for preterm infants.
- Standardized assessment and a combination of pharmacologic and non-pharmacologic interventions are recommended.
- Parents are a vital, underutilized resource for pain management.
Conclusions:
- Addressing pain in preterm infants is critical for their well-being.
- A comprehensive approach involving healthcare providers and parents is necessary.
- Enhanced parental engagement can significantly improve pain relief outcomes.
Abstract:
Infants born preterm are at a high risk for repeated pain exposure in early life. Despite valid tools to assess pain in non-verbal infants and effective interventions to reduce pain associated with medical procedures required as part of their care, many infants receive little to no pain-relieving interventions. Moreover, parents remain significantly underutilized in provision of pain-relieving interventions, despite the known benefit of their involvement. This narrative review provides an overview of the consequences of early exposure to untreated pain in preterm infants, recommendations for a standardized approach to pain assessment in preterm infants, effectiveness of non-pharmacologic and pharmacologic pain-relieving interventions, and suggestions for greater active engagement of parents in the pain care for their preterm infant.
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