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Updated: Oct 2, 2025

Next Generation Sequencing for the Detection of Actionable Mutations in Solid and Liquid Tumors
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Published on: September 20, 2016

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A Contemporary Review of Molecular Therapeutic Targets for Adenoid Cystic Carcinoma

Lauren E Miller1, Vivienne Au1, Tara E Mokhtari1

  • 1Department of Otolaryngology-Head and Neck Surgery, Massachusetts Eye and Ear, Boston, MA 02114, USA.

Cancers
|February 25, 2022
PubMed

Insights

This review covers molecular targets for Adenoid Cystic Carcinoma (ACC), a rare salivary gland cancer. Research highlights the MYB-NFIB translocation as a key driver, with ongoing studies exploring other targets for novel therapies.

Area of Science:

  • Oncology
  • Molecular Biology
  • Genetics

Background:

  • Adenoid Cystic Carcinoma (ACC) is a rare malignant tumor originating in salivary glands.
  • Identifying specific molecular alterations is crucial for developing targeted therapies.

Purpose of the Study:

  • To review recent advances in identifying targetable molecular alterations in ACC.
  • To summarize clinical trials investigating targeted therapies for ACC.

Main Methods:

  • A comprehensive literature search was conducted across PubMed, Medline, and Web of Science.
  • Relevant articles and abstracts were selected through keyword analysis and double peer review.
  • 55 manuscripts detailing molecular targets for ACC were included.

Main Results:

  • The MYB-NFIB translocation is the most studied pathway, implicated in ACC pathogenesis.
  • Other investigated targets include cKIT, EGFR, and NOTCH1, showing limited clinical efficacy.
  • Advances in understanding molecular abnormalities driving ACC are emerging.

Conclusions:

  • Continued investigation into molecular targets is essential for developing effective treatments for ACC.
  • Targeted therapies hold promise for improving outcomes in ACC patients.
Keywords:
adenoid cystic carcinoma (ACC)salivary glandtargeted therapy

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