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Combining two or more treatment methods increases the life span of cancer patients while reducing damage to vital organs or tissue from the overuse of a single treatment. Combination therapy also targets different cancer-inducing pathways, thus reducing the chances of developing resistance to treatment.
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Recent Major Transcriptomics and Epitranscriptomics Contributions toward Personalized and Precision Medicine.

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  • 1Research Institute, Sidra Medicine, Doha, Qatar.

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Transcriptomics and epitranscriptomics are revolutionizing personalized medicine by improving disease diagnostics and understanding. These "other-omics" fields are crucial for advancing precision medicine beyond genomics.

Keywords:
autism spectrum disordercancercardiovascular diseaseepitranscriptomicsintellectual disabilityneurodevelopmental disorderspersonalized medicineprecision medicinetranscriptomics

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Area of Science:

  • Molecular Biology
  • Genetics
  • Biomedical Science

Background:

  • Genomics initiated the era of precision medicine, with significant contributions to understanding disease.
  • Emerging "other-omics" fields, like transcriptomics and epitranscriptomics, are increasingly vital for disease etiology and therapeutic discovery.

Purpose of the Study:

  • To review the impact of transcriptomics and epitranscriptomics on personalized and precision medicine.
  • To summarize key advancements in cancer, cardiovascular disease, and neurodevelopmental disorders.

Main Methods:

  • Review of recent transcriptomic and epitranscriptomic studies.
  • Focus on applications in diagnostics and disease pathophysiology.

Main Results:

  • Transcriptomics and epitranscriptomics show significant progress in diagnostics for major diseases.
  • These fields are crucial for disease pathophysiology research and landscape studies.

Conclusions:

  • Transcriptomics and epitranscriptomics are making vital contributions to precision and personalized medicine.
  • These "other-omics" fields will significantly enhance the gains achieved by genomics.