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Moyamoya disease and syndrome: a review

Zeferino Demartini1,2,3, Bernardo Ca Teixeira1,2, Gelson Luis Koppe2,3

  • 1Complexo Hospital de Clínicas - Universidade Federal do Paraná (UFPR), Curitiba, PR, Brazil.

Radiologia Brasileira
|February 25, 2022
PubMed

Insights

Moyamoya disease is a rare cerebrovascular condition causing progressive artery narrowing. Surgical revascularization offers a promising treatment to prevent strokes and improve patient quality of life.

Area of Science:

  • Neurology
  • Vascular Biology
  • Medical Imaging

Background:

  • Moyamoya disease is a chronic, non-inflammatory cerebrovascular condition.
  • Characterized by progressive stenosis of intracranial carotid arteries and branches.
  • Leads to ischemic or hemorrhagic strokes with significant morbidity and mortality.

Purpose of the Study:

  • To review recent advances in understanding Moyamoya disease.
  • To cover epidemiology, etiology, clinical presentation, and diagnostic imaging.
  • To discuss current and emerging treatment strategies, including surgical revascularization.

Main Methods:

  • Literature review of recent studies on Moyamoya disease.
  • Analysis of epidemiological data, etiological factors, and clinical manifestations.
  • Evaluation of diagnostic imaging techniques and therapeutic interventions.

Main Results:

  • Moyamoya disease involves endothelial hyperplasia and fibrosis.
  • Cerebral angiography reveals characteristic "moyamoya" collateral vessels.
  • Surgical revascularization shows potential in preventing ischemic events.

Conclusions:

  • Moyamoya disease requires comprehensive understanding for effective management.
  • Advances in imaging enhance diagnostic accuracy.
  • Surgical revascularization is a key strategy for improving patient outcomes and quality of life.

Keywords:
Cerebral arterial diseasesCerebral revas-cularizationCerebrovascular disordersIntracranial arterial diseasesMoyamoya disease

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