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Updated: Jul 18, 2026
10:05
The Multi-organ Chip - A Microfluidic Platform for Long-term Multi-tissue Coculture
Published on: April 28, 2015
CoreView: fresh tissue biopsy assessment at the bedside using a millifluidic imaging chip
David J Cooper1, Chuqin Huang2, Dylan A Klavins3
1Department of Bioengineering, University of Washington, 3720 15th Ave NE, Seattle, Washington, USA. eseibel@uw.edu.
Lab on a Chip
|February 25, 2022
Summary
A new 3D printed millifluidic device, CoreView, offers rapid, non-destructive point-of-care assessment for core needle biopsies. This automated system enhances diagnostic accuracy and efficiency for various medical conditions.
Area of Science:
- Biomedical Engineering
- Histopathology
- Medical Diagnostics
Background:
- Minimally invasive core needle biopsies are crucial for disease diagnosis.
- Current methods lack rapid, low-cost, non-destructive point-of-care assessment for intact tissue cores.
Purpose of the Study:
- To develop a proof-of-concept 3D printed millifluidic lab-on-a-chip device for automated handling, processing, and imaging of fresh core needle biopsies.
- To enable rapid adequacy testing at the point-of-care.
Main Methods:
- Development of a 3D printed millifluidic device (CoreView) with modules for biopsy removal, transport, staining, imaging, and storage.
- Implementation of a MATLAB-based biopsy tracking algorithm for automated navigation and detection.
- Demonstration of reliable removal and bidirectional fluid transport of five tissue types with 0.5 mm accuracy.
Main Results:
- Successful automated handling, processing, and imaging of fresh core needle biopsies.
- Demonstrated reliable biopsy removal and transport with high positioning accuracy.
- Validated a biopsy tracking algorithm for automated channel navigation.
Conclusions:
- The CoreView device provides a novel solution for rapid, non-destructive point-of-care assessment of core needle biopsies.
- This technology can improve diagnostic efficiency and accuracy, including specific applications like glomeruli counting in renal biopsies.
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