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A Possible Mechanism for Flecainide Induced Dizziness.

Octavio Garaycochea1, Álvaro Riesgo2, Raquel Manrique-Huarte1

  • 1Department of Otorhinolaryngology, Clinica Universidad de Navarra, University of Navarra.

Otology & Neurotology : Official Publication of the American Otological Society, American Neurotology Society [And] European Academy of Otology and Neurotology
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Summary

Flecainide, an antiarrhythmic drug, can cause dizziness and visual disturbances. A case study suggests this may be due to flecainide-induced bilateral vestibulopathy, affecting the inner ear's balance system.

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Area of Science:

  • Cardiology
  • Neurology
  • Otolaryngology

Background:

  • Flecainide is a Class IC antiarrhythmic medication.
  • Common side effects include dizziness and visual disturbances.

Observation:

  • A 69-year-old male experienced unsteadiness and dizziness after a flecainide dose increase.
  • Diagnostic interventions included otologic examination, video head-impulse testing, vestibular evoked myogenic potentials, audiometry, and MRI.

Findings:

  • Otologic and vestibular assessments confirmed bilateral vestibulopathy.
  • The patient's symptoms correlated with flecainide use.

Implications:

  • This case suggests bilateral vestibulopathy as a potential mechanism for flecainide-associated dizziness and visual disturbances.
  • Further research is warranted to explore the ototoxic effects of flecainide on the vestibular system.