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Targeted Cancer Therapies

Targeted Cancer Therapies

The targeted cancer therapies, also known as “molecular targeted therapies,” take advantage of the molecular and genetic differences between the cancer cells and the normal cells. It needs a thorough understanding of the cancer cells to develop drugs that can target specific molecular aspects that drive the growth, progression, and spread of cancer cells without affecting the growth and survival of other normal cells in the body.
There are several types of targeted therapies against...

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Related Experiment Video

Updated: Oct 2, 2025

An In-House-Built and Light-Emitting-Diode-Based Photodynamic Therapy Device for Enhancing Verteporfin Cytotoxicity in a 2D Cell Culture Model

An In-House-Built and Light-Emitting-Diode-Based Photodynamic Therapy Device for Enhancing Verteporfin Cytotoxicity in a 2D Cell Culture Model

Published on: January 13, 2023

EGFR-Targeted Photodynamic Therapy.

Luca Ulfo¹, Paolo Emidio Costantini¹, Matteo Di Giosia²

¹Dipartimento di Farmacia e Biotecnologie, Alma Mater Studiorum-Università di Bologna, Via Francesco Selmi 3, 40126 Bologna, Italy.

|February 26, 2022

Summary

This summary is machine-generated.

Epidermal growth factor receptor (EGFR)-targeted photodynamic therapy (PDT) shows promise for cancer treatment. Nanobiotechnology enhances photosensitizer delivery for improved efficacy in EGFR-driven cancers.

Keywords:

EGF EGFR PDT affibodies antibodies aptamers ligands nanobodies phages targeting

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Last Updated: Oct 2, 2025

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Anticancer Efficacy of Photodynamic Therapy with Lung Cancer-Targeted Nanoparticles

Anticancer Efficacy of Photodynamic Therapy with Lung Cancer-Targeted Nanoparticles

Published on: December 1, 2016

Area of Science:

Oncology
Nanotechnology
Biochemistry

Background:

Epidermal growth factor receptor (EGFR) is crucial in cancer proliferation and metastasis.
Aberrant EGFR expression and activation are common in human malignancies.
EGFR-targeted therapies offer significant potential for cancer treatment.

Purpose of the Study:

To review nanobiotechnological advancements in EGFR-targeted photodynamic therapy (PDT).
To explore strategies for selective photosensitizer delivery to tumors.
To summarize the chemistry, action, and targeting moieties of PDT sensitizers.

Main Methods:

Review of recent nanobiotechnological strategies for EGFR-targeted PDT.
Recapitulation of photosensitizer chemistry and mechanisms of action.
Summary of advantages and disadvantages of various targeting strategies.

Main Results:

Nanobiotechnology offers promising approaches for EGFR-targeted PDT.
Selective delivery of photosensitizers to tumors is critical for PDT efficacy.
Various targeting moieties have different benefits and drawbacks.

Conclusions:

EGFR-targeted PDT, enhanced by nanobiotechnology, represents a promising non-invasive cancer treatment.
Further research into targeting moieties and delivery systems is needed.
This approach holds potential for future cancer therapy.