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Single and Multiple Stimuli-Responsive Polymer Particles for Controlled Drug Delivery.
Aida López Ruiz1, Ann Ramirez2, Kathleen McEnnis1
1Chemical and Materials Engineering Department, New Jersey Institute of Technology, Newark, NJ 07102, USA.
Pharmaceutics
|February 26, 2022
Summary
Stimuli-responsive polymers offer advanced drug delivery by responding to internal or external triggers. Combining multiple stimuli in polymers enhances targeted drug release and efficacy.
Area of Science:
- Materials Science
- Biomedical Engineering
- Polymer Chemistry
Background:
- Stimuli-responsive polymers are crucial for advanced drug delivery systems.
- Polymeric nanoparticles enhance drug efficacy and reduce toxicity.
- Stimuli-responsive polymers enable controlled drug release in specific body regions.
Purpose of the Study:
- To review stimuli-responsive polymers for controlled drug delivery.
- To discuss internal and external stimuli for drug release.
- To highlight chemical structures for stimuli-responsive polymers.
Main Methods:
- Review of internal stimuli (pH, redox, temperature).
- Review of external stimuli (light, ultrasound).
- Analysis of chemical structures for stimuli-responsive polymers.
Main Results:
- Internal stimuli trigger changes within the body.
- External stimuli utilize external sources for controlled release.
- Combining multiple stimuli enhances specificity in drug delivery.
Conclusions:
- Stimuli-responsive polymers are key to targeted drug delivery.
- Multi-stimuli responsive polymers represent a significant advancement.
- This review focuses on combining stimuli for enhanced drug delivery applications.
