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Polymeric Nanostructures Containing Proteins and Peptides for Pharmaceutical Applications
Antiopi Vardaxi1, Martha Kafetzi1, Stergios Pispas1
1Theoretical and Physical Chemistry Institute, National Hellenic Research Foundation, 48 Vassileos Constantinou Avenue, 11635 Athens, Greece.
Polymers
|February 26, 2022
Summary
Polymeric nanostructures offer advanced delivery for protein and peptide therapeutics, overcoming challenges like short half-life and instability. These biocompatible vehicles enhance drug bioavailability and enable targeted administration for various diseases.
Area of Science:
- Biotechnology
- Materials Science
- Pharmaceutical Sciences
Background:
- Proteins and peptides are crucial therapeutics for diseases like cancer and diabetes.
- Their clinical application is limited by instability, short half-life, and delivery challenges.
Purpose of the Study:
- To review polymeric nanostructures as delivery vehicles for proteins and peptides.
- To discuss their role in enhancing therapeutic efficacy and overcoming delivery obstacles.
Main Methods:
- Review of scientific literature on polymer-based nanostructures for drug delivery.
- Analysis of block copolymer nanostructures for protein encapsulation and conjugation.
Main Results:
- Polymeric nanostructures provide enhanced bioavailability and biocompatibility.
- These nanovehicles offer tunable physicochemical properties and colloidal stability.
- They facilitate the incorporation of both hydrophobic and hydrophilic bioactive molecules.
Conclusions:
- Polymeric nanostructures are effective for protein and peptide drug delivery.
- They represent a promising platform for developing advanced therapeutics.
- Further research into their applications is anticipated.
