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Matrix Metalloproteinase-10 in Kidney Injury Repair and Disease

Xiaoli Sun1, Youhua Liu1,2

  • 1State Key Laboratory of Organ Failure Research, National Clinical Research Center of Kidney Disease, Division of Nephrology, Nanfang Hospital, Southern Medical University, Guangzhou 510515, China.

International Journal of Molecular Sciences
|February 26, 2022
PubMed

Insights

Matrix metalloproteinase-10 (MMP-10) plays dual roles in kidney health, protecting against acute injury but worsening chronic disease and cancer. Targeting MMP-10 presents therapeutic challenges due to its complex functions.

Area of Science:

  • Nephrology
  • Biochemistry
  • Oncology

Background:

  • Matrix metalloproteinase-10 (MMP-10) is an enzyme that degrades extracellular matrix.
  • MMP-10 expression increases in acute kidney injury (AKI), chronic kidney disease (CKD), and renal cell carcinoma (RCC).

Purpose of the Study:

  • To review the multifaceted roles of MMP-10 in various kidney conditions.
  • To explore the mechanisms underlying MMP-10's functions in kidney disease and cancer.
  • To discuss MMP-10 as a potential therapeutic target.

Main Methods:

  • Literature review of studies on MMP-10 in kidney diseases.
  • Analysis of MMP-10's substrate cleavage and functional consequences.
  • Discussion of therapeutic strategies and challenges.

Main Results:

  • MMP-10 is reno-protective in AKI by aiding tubular repair via HB-EGF.
  • MMP-10 exacerbates kidney injury in CKD by degrading ZO-1, impairing filtration.
  • MMP-10 promotes cancer invasion in RCC and is detectable in circulation inversely correlating with renal function.

Conclusions:

  • MMP-10 exhibits context-dependent roles in kidney pathophysiology.
  • MMP-10's dual actions in kidney injury and cancer highlight its complexity.
  • Developing specific MMP-10 inhibitors is challenging but crucial for therapeutic development.
Keywords:
HB-EGFMMP-10ZO-1acute kidney injurychronic kidney diseaseproteinuriarenal fibrosis

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