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Spatial navigation performance in people with multiple sclerosis-a large-scale online study.

Ineke J M van der Ham1, Vasiliki Koutzmpi1, Milan N A van der Kuil1

  • 1Department of Health, Medical and Neuropsychology, Leiden University, Wassenaarseweg 52 AK, Leiden 2333 the Netherlands.

Multiple Sclerosis and Related Disorders
|February 26, 2022
PubMed
Summary
This summary is machine-generated.

People with Multiple Sclerosis (MS) experience significant impairments in spatial navigation, affecting daily life. Cognitive issues in MS patients further worsen navigation challenges, highlighting the need for targeted support.

Keywords:
AmbulationCognitive impairmentMultiple sclerosisNavigation impairmentSelf-reportSpatial navigation

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Area of Science:

  • Neuroscience
  • Human Mobility Studies

Background:

  • Spatial navigation is vital for autonomy and quality of life.
  • Acquired brain injuries often impair navigation, but MS-specific impacts remain understudied.
  • Understanding navigation deficits in MS can enhance patient care and mobility.

Purpose of the Study:

  • To quantify objective and subjective navigation performance in individuals with Multiple Sclerosis (MS).
  • To investigate the influence of ambulation and self-reported cognitive function on navigation in MS.
  • To compare navigation abilities between people with MS and healthy controls.

Main Methods:

  • A large cohort of 359 people with MS and matched controls completed validated questionnaires (Wayfinding Questionnaire, Expanded Disability Status Scale, MS Neuropsychological Screening Questionnaire).
  • Objective navigation was assessed using a virtual environment online test.
  • Within the MS group, the impact of ambulation and cognitive self-reports was analyzed.

Main Results:

  • Individuals with MS demonstrated significantly lower objective and subjective navigation performance compared to controls.
  • Self-reported cognitive performance was a substantial predictor of navigation ability in people with MS.
  • Mobility and disability status also showed associations with navigation challenges.

Conclusions:

  • Spatial navigation difficulties are prevalent in people with MS.
  • Cognitive impairments exacerbate navigation problems in MS.
  • These findings underscore the importance of addressing navigation and cognitive function in MS management.