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Micro-patterned cell populations as advanced pharmaceutical drugs with precise functional control.

Hui Che1, Mischa Selig2, Bernd Rolauffs3

  • 1G.E.R.N. Research Center for Tissue Replacement, Regeneration & Neogenesis, Department of Orthopedics and Trauma Surgery, Faculty of Medicine, Medical Center-Albert-Ludwigs-University of Freiburg, 79085 Freiburg im Breisgau, Germany; Orthopedics and Sports Medicine Center, Suzhou Municipal Hospital (North District), Nanjing Medical University Affiliated Suzhou Hospital, Suzhou 215006, China.

Advanced Drug Delivery Reviews
|February 26, 2022
PubMed
Summary

Micro-patterning human cells offers precise control over their functions, enhancing their potential as therapeutic drug delivery systems. This approach promises improved cell-based therapies by guiding cell behavior for pharmaceutical applications.

Keywords:
Adhesion siteArtificial extracellular matrixCell-instructiveDrug deliveryFunctional controlGeometric controlMicro-patternPatterningTherapeutic cells

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Area of Science:

  • Biomaterials Science
  • Cell Biology
  • Regenerative Medicine

Background:

  • Human cells serve as advanced pharmaceuticals and drug delivery vehicles.
  • Achieving functional control of implanted cells remains a significant challenge.
  • Micro-patterning presents a novel strategy to overcome these limitations.

Purpose of the Study:

  • To review the therapeutic potential of micro-patterned cells.
  • To summarize cell functions controllable via micro-patterning.
  • To detail micro-pattern designs and fabrication technologies.

Main Methods:

  • Comprehensive literature review of micro-patterning techniques and applications.
  • Analysis of established micro-pattern designs and fabrication methods.
  • Exploration of cell functions modulated by micro-patterning.

Main Results:

  • Micro-patterning successfully controls cell morphogenesis, mechanics, proliferation, differentiation, and collective behavior.
  • Various micro-pattern designs and fabrication technologies are available.
  • Potential therapeutic applications for micro-patterned cells are identified.

Conclusions:

  • Micro-patterning enables precise control over cellular functions for therapeutic applications.
  • This approach facilitates the development of cells as pharmaceutical products.
  • Further development is needed to realize micro-patterned therapeutic cells.