In Situ Electrospinning of Aggregation-Induced Emission Nanofibrous Dressing for Wound Healing

Rapid wound dressing and effective antibacterial therapy that meet the extreme requirements of emergency situations are urgently needed for treating skin wounds. Here, an in situ deposited and personalized nanofibrous dressing is reported which can be directly electrospun on skin wounds by a handheld electrospinning device and perfectly fits different wounds of various sizes. Moreover, an aggregation-induced emission luminogen with photodynamic therapy effect is loaded in the nanofibrous dressings which endows the dressing's long-term antibacterial activity during the wound healing process. The in situ electrospun nanofibers show excellent antimicrobial activity against Staphylococcus aureus (S. aureus) and methicillin-resistant Staphylococcus aureus. In vivo studies demonstrate that these antibacterial nanofibrous dressings can effectively reduce inflammation and significantly accelerate wound healing. Such an in situ produced antibacterial dressing is promising as a total solution for treating emergencies, including patient-specific clinical wounds and military injuries.