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Mechanisms of biologic aging.

A K Balin, R G Allen

    Dermatologic Clinics
    |July 1, 1986
    PubMed
    Summary

    Aging is influenced by environmental factors and thermodynamic processes. Oxidative stress and other molecular changes increase system entropy, governing the aging rate.

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    Area of Science:

    • Gerontology and molecular biology
    • Thermodynamics and biophysics

    Background:

    • Theories of aging often lack a fundamental thermodynamic basis.
    • Environmental factors' influence on genetic events in aging requires further elucidation.

    Purpose of the Study:

    • To review the progression of thought on aging mechanisms.
    • To emphasize theories with a thermodynamic foundation.
    • To propose a unifying mechanism for the aging process.

    Main Methods:

    • Literature review and theoretical synthesis.
    • Focus on aging theories with thermodynamic principles.
    • Analysis of oxidative stress and other thermodynamic processes.

    Main Results:

    • Identified key thermodynamic processes contributing to aging, including oxidative stress, amino-acid racemization, and nonenzymatic glycosylation.
    • Proposed that cumulative molecular damage increases the net entropy of living systems.
    • Linked altered cellular function to these thermodynamic alterations.

    Conclusions:

    • The aging rate is governed by the cumulative effects of thermodynamic processes.
    • Environmental factors interact with genetic events through these thermodynamic pathways.
    • A thermodynamic framework provides a fundamental explanation for the aging process.

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