Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Percutaneous absorption in the aged.

K V Roskos, R H Guy, H I Maibach

    Dermatologic Clinics
    |July 1, 1986
    PubMed
    Summary

    As humans age, there is a notable lack of consensus regarding changes in percutaneous absorption. Further research is crucial to understand how skin barrier function alters with age, impacting dermatopharmacology and drug delivery.

    Related Concept Videos

    You might also read

    Related Articles

    Articles linked to this work by shared authors, journal, and citation graph.

    Sort by
    Same author

    The sodium lauryl sulfate model: an overview.

    Contact dermatitis·1995
    Same author

    Textile dermatitis: an update. (I). Resins, additives and fibers.

    Contact dermatitis·1995
    Same author

    A local lymph-node assay validation study of a structure-activity relationship model for contact allergens.

    Archives of dermatological research·1995
    Same author

    Horizons in pharmacologic intervention in allergic contact dermatitis.

    Journal of the American Academy of Dermatology·1994
    Same author

    Topical FK506--clinical potential or laboratory curiosity?

    Dermatology (Basel, Switzerland)·1994
    Same author

    Topical FK506: suppression of allergic and irritant contact dermatitis in the guinea pig.

    Archives of dermatological research·1994

    Area of Science:

    • Dermatology
    • Gerontology
    • Pharmacology

    Background:

    • Significant alterations in skin barrier function may occur with aging.
    • There is a lack of consensus on how percutaneous absorption changes in older adults.
    • Understanding age-related skin changes is vital for dermatopharmacology and dermatotoxicology.

    Purpose of the Study:

    • To address the gap in knowledge regarding the relationship between aging, percutaneous penetration, and molecular properties.
    • To investigate how the skin barrier function changes with increasing age.
    • To establish a clear understanding of age-related alterations in percutaneous absorption.

    Main Methods:

    • Review of existing data on percutaneous absorption and aging.
    • Analysis of factors influencing skin barrier function in different age groups.
    • Identification of knowledge gaps in dermatologic research related to aging.

    Main Results:

    • Existing data suggest potential significant alterations in skin barrier function with age.
    • A clear relationship between aging, percutaneous penetration, and molecular properties remains undefined.
    • The consensus on age-related changes in percutaneous absorption is currently lacking.

    Conclusions:

    • Establishing how skin barrier function changes with age is crucial for improving health outcomes in aging populations.
    • Understanding age-related percutaneous absorption is essential for optimizing dermatologic drug delivery and safety.
    • Further research is needed to define the precise impact of aging on skin barrier function and percutaneous absorption.

    Related Experiment Videos