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Silver nanotriangle array based LSPR sensor for rapid coronavirus detection.

Yanjun Yang¹, Jackelyn Murray², James Haverstick³

¹School of Electrical and Computer Engineering, College of Engineering, The University of Georgia, Athens, GA 30602, USA.

Sensors and Actuators. B, Chemical

|February 28, 2022

Summary

This summary is machine-generated.

A new silver nanotriangle sensor detects SARS-CoV-2 rapidly and cost-effectively. This localized surface plasmon resonance (LSPR) sensor shows high sensitivity and specificity for COVID-19 detection, offering a potential point-of-care diagnostic tool.

Keywords:

Coronavirus NL63 Coronavirus detection Localized surface plasmon resonance (LSPR)SARS-CoV-2 spike receptor binding domain Silver nanotriangle array

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Area of Science:

Nanotechnology
Biosensing
Infectious Disease Diagnostics

Background:

The COVID-19 pandemic necessitates rapid, portable, and cost-effective SARS-CoV-2 detection methods.
Existing diagnostic tools may face limitations in speed, portability, or cost for widespread point-of-care application.

Purpose of the Study:

To develop a novel optical sensor for the rapid detection of SARS-CoV-2.
To functionalize silver nanotriangle arrays with human angiotensin-converting enzyme 2 (ACE2) protein for enhanced viral binding.

Main Methods:

Fabrication of an ACE2-functionalized silver nanotriangle (AgNT) array.
Utilizing localized surface plasmon resonance (LSPR) for signal transduction.
Validation using SARS-CoV-2 spike receptor-binding domain (RBD) protein and CoV NL63 virus.

Main Results:

The AgNT array LSPR sensor demonstrated high sensitivity and specificity for detecting viral proteins and viruses.
A linear relationship was observed between LSPR wavelength shift and the logarithm of analyte concentration.
Achieved limits of detection: 0.83 pM for spike RBD protein, 391 PFU/mL for CoV NL63 in buffer, and 625 PFU/mL in untreated saliva.
Detection time was less than 20 minutes.

Conclusions:

The developed AgNT array optical sensor is a promising platform for rapid, sensitive, and specific detection of SARS-CoV-2.
This technology has the potential to serve as a rapid point-of-care diagnostic tool for COVID-19.
The sensor's performance in buffer and saliva highlights its applicability in clinical settings.