Serologic Abnormalities in Macular Lymphocytic Arteritis with Case Presentation
Nicole R Bender1, Elizabeth L Bisbee1, Douglas Robins1
1Dermatology, University of Florida, Gainesville, Florida, USA.
Case Reports in Dermatology
|February 28, 2022
Summary
Macular lymphocytic arteritis (MLA) is a rare skin vasculitis. This case highlights unusual serologic abnormalities, expanding our understanding of this indolent condition.
Area of Science:
- Dermatology
- Rheumatology
- Immunology
Background:
- Macular lymphocytic arteritis (MLA) is an indolent cutaneous small-medium-vessel vasculitis.
- It is characterized by widespread asymptomatic livedo racemosa.
- Previous reports noted serologic abnormalities like elevated ESR and antiphospholipid syndrome antibodies.
Observation:
- This report details a case of MLA with multiple, previously unreported serologic abnormalities.
- Specific antibodies identified include anti-U1 ribonucleotide protein, anti-RNA polymerase III, anti-smith, and anti-proteinase 3.
- The patient presented with widespread asymptomatic livedo racemosa.
Findings:
- The case expands the known serologic profile of MLA.
- It demonstrates a broader spectrum of autoimmune associations than previously recognized.
- The findings emphasize the complexity of MLA's underlying pathophysiology.
Implications:
- This case broadens the diagnostic considerations for MLA.
- It suggests a potential link between MLA and a wider range of autoimmune markers.
- Further research is warranted to understand the clinical significance of these novel antibody associations in MLA.
Keywords:
Antiphospholipid antibodiesLupus autoantibodiesLymphocytic thrombophilic arteritisMacular lymphocytic arteritisSerologic abnormalities
