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Updated: Oct 2, 2025

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Serologic Abnormalities in Macular Lymphocytic Arteritis with Case Presentation.

Nicole R Bender1, Elizabeth L Bisbee1, Douglas Robins1

  • 1Dermatology, University of Florida, Gainesville, Florida, USA.

Case Reports in Dermatology
|February 28, 2022
PubMed
Summary

Macular lymphocytic arteritis (MLA) is a rare skin vasculitis. This case highlights unusual serologic abnormalities, expanding our understanding of this indolent condition.

Keywords:
Antiphospholipid antibodiesLupus autoantibodiesLymphocytic thrombophilic arteritisMacular lymphocytic arteritisSerologic abnormalities

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Area of Science:

  • Dermatology
  • Rheumatology
  • Immunology

Background:

  • Macular lymphocytic arteritis (MLA) is an indolent cutaneous small-medium-vessel vasculitis.
  • It is characterized by widespread asymptomatic livedo racemosa.
  • Previous reports noted serologic abnormalities like elevated ESR and antiphospholipid syndrome antibodies.

Observation:

  • This report details a case of MLA with multiple, previously unreported serologic abnormalities.
  • Specific antibodies identified include anti-U1 ribonucleotide protein, anti-RNA polymerase III, anti-smith, and anti-proteinase 3.
  • The patient presented with widespread asymptomatic livedo racemosa.

Findings:

  • The case expands the known serologic profile of MLA.
  • It demonstrates a broader spectrum of autoimmune associations than previously recognized.
  • The findings emphasize the complexity of MLA's underlying pathophysiology.

Implications:

  • This case broadens the diagnostic considerations for MLA.
  • It suggests a potential link between MLA and a wider range of autoimmune markers.
  • Further research is warranted to understand the clinical significance of these novel antibody associations in MLA.