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Updated: Oct 2, 2025
10:27
In Silico Identification and Characterization of circRNAs During Host-Pathogen Interactions
Published on: October 21, 2022
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Chimeric Peptides/Proteins Encoded by circRNA: An Update on Mechanisms and Functions in Human Cancers
Faiz Ali Khan1,2,3, Bernard Nsengimana1, Nazeer Hussain Khan1
1Laboratory of Cell Signal Transduction, Department of Biochemistry and Molecular Biology, School of Basic Medical Sciences, Henan University, Kaifeng, China.
Frontiers in Oncology
|February 28, 2022
Summary
Circular RNAs (circRNAs) are crucial in cellular processes and cancer. They can encode peptides that impact cancer progression and serve as potential diagnostic biomarkers and therapeutic targets.
Area of Science:
- Cellular Biology
- Molecular Biology
- Oncology
Background:
- Circular RNAs (circRNAs) are gaining attention for their roles in cellular functions.
- Their unique properties include high conservation and stability.
- circRNAs are involved in gene regulation, RNA processing, and epigenetic modifications.
Purpose of the Study:
- To review the biogenesis and functional mechanisms of circRNAs.
- To highlight circRNAs that encode peptides/proteins.
- To discuss the potential of circRNAs in cancer diagnosis and therapy.
Main Methods:
- Literature review focusing on circRNA biogenesis.
- Analysis of functional mechanisms of circRNAs.
- Emphasis on circRNA-encoded peptides and their roles in cancer.
Main Results:
- circRNAs are involved in critical cellular activities like proliferation, invasion, and apoptosis.
- circRNA-encoded peptides modulate signaling pathways implicated in cancer development.
- These peptides show potential as cancer biomarkers and therapeutic targets.
Conclusions:
- circRNAs play significant roles in various cellular processes and cancer.
- circRNA-encoded peptides are key mediators of cancer progression.
- circRNAs offer promising opportunities for cancer diagnostics and therapeutics.
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