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Estrogen-Induced Extracellular Calcium Influx Promotes Endometrial Cancer Progress by Regulating Lysosomal Activity

Boqiang Shen1, Juan Hao1, Yanying Lin2

  • 1Department of Obstetrics and Gynecology, Peking University People's Hospital, Beijing, China.

Frontiers in Medicine
|February 28, 2022
PubMed
Summary

High serum calcium levels correlate with advanced endometrial cancer (EC) progression. Estrogen-induced calcium influx impacts mitochondrial reactive oxygen species (ROS) and lysosome activity, offering potential therapeutic targets for EC.

Keywords:
calcium homeostasisendometrial cancer (EC)estrogenprognosis (carcinoma)serum calcium

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