Related Experiment Video

Updated: Oct 2, 2025

Noninvasive Assessment of Cardiac Abnormalities in Experimental Autoimmune Myocarditis by Magnetic Resonance Microscopy Imaging in the Mouse
12:24

Noninvasive Assessment of Cardiac Abnormalities in Experimental Autoimmune Myocarditis by Magnetic Resonance Microscopy Imaging in the Mouse

Published on: June 20, 2014

10.1K

Pericarditis and myocarditis after COVID-19 mRNA vaccination in a nationwide setting

Jonathan Yap1, Mun Yee Tham, Jalene Poh

  • 1Department of Cardiology, National Heart Centre Singapore, Singapore.

Annals of the Academy of Medicine, Singapore
|February 28, 2022
PubMed
Abstract

Insights

COVID-19 mRNA vaccination is associated with an increased incidence of pericarditis and myocarditis, particularly in younger males. This nationwide study in Singapore highlights these rare risks following vaccination.

Area of Science:

  • Cardiology
  • Vaccinology
  • Public Health

Background:

  • Reports suggest a link between COVID-19 mRNA vaccines and rare cases of pericarditis and myocarditis.
  • Nationwide population-based data on this association remain limited.

Purpose of the Study:

  • To determine the incidence of pericarditis and myocarditis following COVID-19 mRNA vaccination.
  • To analyze these incidences by age and sex in Singapore's mass vaccination program.

Main Methods:

  • Retrospective analysis of adjudicated cases reported to the vaccine safety committee (Jan-July 2021).
  • Comparison of post-vaccination incidence with background myocarditis rates in Singapore.

Main Results:

  • 34 cases (9 pericarditis, 14 myocarditis, 11 both) reported after 7,183,889 mRNA vaccine doses.
  • Highest pericarditis incidence in males aged 12-19 (1.11/100,000 doses).
  • Increased myocarditis incidence in males aged 12-19 (3.72/100,000 doses) and 20-29 (0.98/100,000 doses), with 80% of myocarditis cases being male.

Conclusions:

  • COVID-19 mRNA vaccination is associated with an increased incidence of pericarditis and myocarditis.
  • Younger males, particularly those aged 12-29, show a higher-than-expected incidence of these conditions.

More Related Videos

Viral Transgene Expression in Rodent Hearts and the Assessment of Cardiac Arrhythmia Risk05:15

Viral Transgene Expression in Rodent Hearts and the Assessment of Cardiac Arrhythmia Risk

Published on: July 27, 2022

1.7K
Percutaneous Contrast Echocardiography-guided Intramyocardial Injection and Cell Delivery in a Large Preclinical Model14:24

Percutaneous Contrast Echocardiography-guided Intramyocardial Injection and Cell Delivery in a Large Preclinical Model

Published on: January 21, 2018

11.8K

Related Concept Videos

Myocarditis II: Clinical Features and Diagnostic Tests01:27

Myocarditis II: Clinical Features and Diagnostic Tests

Myocarditis is an inflammation of the heart muscle. The symptoms vary widely, encompassing asymptomatic presentations to severe, acute manifestations.Clinical PresentationAsymptomatic cases: In some instances, myocarditis may be asymptomatic, with the infection resolving without intervention. These cases often go undetected unless discovered incidentally through diagnostic imaging or tests conducted for other reasons.General Early Symptoms: Early symptoms of myocarditis are non-specific and can...
36
Myocarditis III: Medical Management01:14

Myocarditis III: Medical Management

Myocarditis: Comprehensive Medical ManagementMyocarditis, the heart muscle inflammation, requires a comprehensive medical management strategy that addresses the underlying cause, provides supportive care, manages symptoms, and reduces cardiac workload.Infections and Autoimmune CausesAdminister appropriate antimicrobial therapy when an infectious agent causes myocarditis. For instance, penicillin treats infections caused by Group A Streptococcus. In cases where autoimmune processes are...
27
Myocarditis I: Introduction01:21

Myocarditis I: Introduction

Myocarditis is inflammation of the myocardium, which is the muscular layer of the heart.EtiologyMyocarditis has a diverse etiology, including a wide range of infectious and non-infectious causes:Infectious CausesViral: Common viruses include Coxsackie A and B, adenovirus, parvovirus B19, enteroviruses, and influenza A.Bacterial: Examples include infections caused by Streptococcus, Staphylococcus, and Mycoplasma species.Rickettsial: Infections like Rocky Mountain spotted fever can result in...
52
Pericarditis I: Introduction01:22

Pericarditis I: Introduction

Pericarditis is defined as the inflammation of the pericardium, the thin, sac-like membrane surrounding the heart. This condition can cause significant chest pain and other symptoms, often necessitating medical intervention. The pericardium has two layers: the inner visceral layer and the outer parietal layer, separated by a small amount of fluid that reduces friction during heartbeats.Types of PericarditisPericarditis can be classified into several types based on the duration and nature of the...
32
Pericarditis II: Clinical Features and Diagnostic Tests01:19

Pericarditis II: Clinical Features and Diagnostic Tests

Pericarditis is distinguished by inflammation of the pericardium, the fibrous sac that encases the heart. It can be acute, lasting less than six weeks, or chronic, persisting for over three months. Understanding its clinical manifestations and diagnostic findings is crucial for timely and effective management.Clinical ManifestationsWhile pericarditis can be asymptomatic, it usually presents with characteristic symptoms such as:Chest Pain: The most characteristic symptom of pericarditis is chest...
47
Pericarditis III: Medical Management01:17

Pericarditis III: Medical Management

The primary objectives of managing pericarditis are to determine the underlying cause, provide effective therapy for treatment and symptom relief, and promptly detect signs and symptoms of cardiac tamponade. The following outlines the essential aspects of medical management for pericarditis:ObjectivesDetermine the Cause: Identifying the underlying cause of pericarditis is crucial for targeted treatment. Causes include viral infections, autoimmune diseases, post-cardiac injury syndrome, and...
44