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Updated: Oct 2, 2025

Facile Preparation of 2Z,4E-Dienamides by the Olefination of Electron-deficient Alkenes with Allyl Acetate
Published on: June 21, 2017
Organoselenium-Catalyzed Cross-Dehydrogenative Coupling of Alkenes and Azlactones
1Institute of Organic Chemistry and MOE Key Laboratory of Bioinorganic and Synthetic Chemistry, School of Chemistry, Sun Yat-Sen University, Guangzhou 510006, P. R. China.
Abstract:
The carbon-carbon bond-forming cross-dehydrogenative coupling of alkenes and azlactones by organoselenium catalysis involving a high-valent para-methoxyphenyl selenium species is disclosed. A series of α,α-disubstituted α-amino acid derivatives were obtained in excellent regioselectivities through vinyl or allylic C-H functionalization. The generality of the method was elucidated by the cross-coupling of an alkene with an oxindole and the direct functionalization of electron-rich arenes with azlactones.
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