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Pediatric Scleritis: An Update
Maria Tarsia1, Carla Gaggiano1,2, Elisa Gessaroli2
1Clinical Pediatrics, Department of Molecular Medicine and Development, University of Siena, Siena, Italy.
Insights
Posterior idiopathic scleritis is common in children, but other forms can signal systemic diseases. Prompt diagnosis and tailored treatment are crucial for preventing ocular and systemic complications.
Area of Science:
- Ophthalmology
- Pediatric Rheumatology
Background:
- Posterior idiopathic scleritis is the most common scleritis type in children.
- Anterior and necrotizing scleritis can also occur, sometimes linked to systemic disorders.
Purpose of the Study:
- To highlight the importance of recognizing systemic associations in childhood scleritis.
- To emphasize the need for prompt diagnosis and multidisciplinary work-up to prevent complications.
Main Methods:
- Review of clinical presentations and diagnostic approaches for childhood scleritis.
- Discussion of potential infectious and autoimmune etiologies.
- Emphasis on multidisciplinary diagnostic strategies.
Main Results:
- Childhood scleritis, while often posterior and idiopathic, can indicate underlying systemic conditions.
- Prompt identification of infectious or autoimmune causes (e.g., ANCA-associated vasculitis, sarcoidosis) is vital.
- Systemic associations require specific management to avoid severe outcomes.
Conclusions:
- Childhood scleritis necessitates a thorough diagnostic evaluation to exclude systemic diseases.
- Treatment must be individualized based on scleritis type, severity, and associated conditions.
- Effective management preserves visual acuity and enhances quality of life.
Abstract:
Posterior idiopathic scleritis is the most common type of scleritis observed in childhood. Nevertheless, anterior and even necrotizing inflammatory scleritis may occur as well. Although less frequently than in the adult population, scleral inflammation can be associated with systemic disorders, which should be promptly recognized and treated to avoid both ocular and systemic complications. Hence, a multidisciplinary diagnostic work-up should be performed to rule out primarily infectious and autoimmune causes, such as viral and bacterial infections, anti-neutrophil cytoplasmic antibodies (ANCA)-associated vasculitis, pediatric sarcoidosis, Behçet's disease and HLA-B27-associated diseases. Treatment of scleritis should aim to control ocular inflammation, relieve symptoms and prevent relapses, to avoid complications, preserve visual acuity and improve the child's quality of life. It should be tailored to the patient, considering the type and severity of scleritis, the possible identification of an infectious cause or the presence of an associated rheumatologic condition.
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