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Cell surface changes in the developing optic nerve of mice.

R D Lund, V H Perry, C F Lagenaur

    The Journal of Comparative Neurology
    |May 22, 1986
    PubMed
    Summary
    This summary is machine-generated.

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    An antibody targeting the M6 cell surface protein inhibits neurite outgrowth. In developing mice, M6 expression changes in the optic nerve suggest roles in neural development and myelination.

    Area of Science:

    • Neuroscience
    • Developmental Biology
    • Cell Biology

    Background:

    • A novel antibody targets the M6 cell surface protein, previously shown to inhibit neurite outgrowth in vitro.
    • The M6 protein is present in the developing mouse's primary optic pathway at birth.

    Purpose of the Study:

    • To investigate the expression pattern of the M6 protein in the developing mouse optic pathway.
    • To correlate M6 expression changes with optic pathway maturation, membrane development, and myelination.

    Main Methods:

    • Immunohistochemical staining using an antibody against the M6 protein.
    • Analysis of M6 expression in the optic nerve and retina of developing and adult mice.

    Main Results:

    • M6 antibody staining was observed throughout the primary optic pathway at birth.

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  • Staining diminished in the optic nerve's proximal segment within the first week and centrally by the second week.
  • M6 expression persisted in the adult retina's optic fiber layer, indicating axonal expression limited to proximal and terminal regions.

    • Conclusions:

    • Axonal expression of the M6 antigen in the mature optic nerve is restricted to the proximal few millimeters and the terminal region.
    • Dynamic changes in M6 expression correlate with the maturation of the optic pathway.
    • These findings suggest a role for M6 in membrane maturation and myelination processes during neural development.