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Updated: Oct 2, 2025

Intracavernosal Pressure Recording to Evaluate Erectile Function in Rodents
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Modulation of SIRT1 expression improves erectile function in aged rats.

Wen Yu1, Jing Wang1, Yu-Tian Dai1

  • 1Institute of Andrology, Nanjing Drum Tower Hospital, The Affiliated Hospital of Nanjing University Medical School, Nanjing 210000, China.

Asian Journal of Andrology
|March 1, 2022
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Summary

Silent information regulator 1 (SIRT1) activation improves aging-related erectile dysfunction. Resveratrol treatment enhanced erectile function and tissue health, with added tadalafil boosting effects. SIRT1 shows potential as a therapeutic target for erectile dysfunction.

Keywords:
SIRT1 expressionapoptosiserectile functionnitric oxide/cyclic guanosine monophosphate signalingoxidative stress

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Area of Science:

  • Biomedical Science
  • Aging Research
  • Urology

Background:

  • Silent information regulator 2-related enzyme 1 (SIRT1) is an aging-associated protein.
  • Erectile dysfunction (ED) is a common condition associated with aging.
  • The role of SIRT1 in aging-related ED requires further investigation.

Purpose of the Study:

  • To evaluate the therapeutic potential of SIRT1 activation in a rat model of aging-related erectile dysfunction.
  • To investigate the effects of resveratrol (Res) and niacinamide (NAM) on erectile function and related molecular pathways.
  • To determine the combined effect of Resveratrol and tadalafil (Tad) on aging-related ED.

Main Methods:

  • Aged Sprague-Dawley rats were treated with Resveratrol, Niacinamide, or Resveratrol + Tadalafil for 8 weeks.
  • Erectile function was assessed by measuring intracavernosal pressure (ICP)/mean systemic arterial pressure (MAP) ratio.
  • Cavernosal tissues were analyzed for histological changes, apoptosis, nitric oxide (NO)/cyclic guanosine monophosphate (cGMP), oxidative stress markers (SOD/MDA), and protein expression (SIRT1, p53, FOXO3a).

Main Results:

  • Resveratrol treatment significantly improved erectile function, increased smooth muscle and endothelial content, elevated NO/cGMP and SOD levels, and reduced apoptosis and MDA.
  • Combination therapy with Resveratrol and Tadalafil further enhanced these positive effects.
  • SIRT1 expression increased with Resveratrol, while p53 and FOXO3a levels decreased. Niacinamide (SIRT1 inhibitor) showed adverse effects.

Conclusions:

  • SIRT1 activation ameliorates aging-related erectile dysfunction.
  • Resveratrol demonstrates therapeutic potential for ED, with synergistic effects when combined with tadalafil.
  • SIRT1 represents a promising therapeutic target for the treatment of age-associated erectile dysfunction.