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Related Concept Videos

Skin Cancer01:30

Skin Cancer

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Skin cancer is a type of cancer that occurs when there is an abnormal growth of skin cells, usually triggered by damage to the DNA within the skin cells. It is primarily caused by exposure to ultraviolet (UV) radiation from the sun or artificial sources like tanning beds. Skin cancer is the most common type of cancer worldwide, and its incidence continues to rise.
Basal Cell Carcinoma (BCC): BCC is the most common type of skin cancer, accounting for about 80% of cases. It typically develops in...
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Multipotency and Niche of Bulge Stem Cell01:06

Multipotency and Niche of Bulge Stem Cell

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A hair follicle or HF is a small part of the skin that produces the hair shaft. Paul Gerson Unna was the first to observe a bulge in the human hair follicle's outer root sheath (ORS). The bulge is present between the sebaceous gland and the arrector pili muscle and is the niche for hair follicle stem cells (HFSCs). The bulge is also a niche for melanocyte stem cells, and their loss results in graying of hair. The HFSCs express Sox9 and Lhx2, which help them maintain stemness and prevent...
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Distinctive Features of Adult Stem Cells vs Cancer Stem Cells01:18

Distinctive Features of Adult Stem Cells vs Cancer Stem Cells

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A stem cell is an unspecialized cell that can divide without limit as needed and can, under specific conditions, differentiate into specialized cells.
Adult stem cells
Adult stem cells are tissue-specific; hence, they divide to develop the tissue from which they originate. One type of adult stem cell is the epithelial stem cell, which gives rise to the keratinocytes in the multiple layers of epithelial cells in the epidermis of the skin. Adult bone marrow has three distinct types of stem cells:...
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Renewal of Skin Epidermal Stem Cells01:12

Renewal of Skin Epidermal Stem Cells

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The skin is divided into epidermis, dermis, and hypodermis, the skin's outermost, middle, and inner layers. The human epidermal layer regularly undergoes renewal, where old, dead cells are replaced by new cells. Epidermal stem cells or EpiSCs divide and differentiate to restore the lost cells. For the renewal process, some EpiSCs continuously self-renew. In contrast, few others differentiate into transit-amplifying cells, which later form prickle or spinous cells, followed by granular...
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Classification of Epithelial Tissues: Stratified Epithelium01:29

Classification of Epithelial Tissues: Stratified Epithelium

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Stratified epithelium consists of several stacked layers of cells. They provide the durability to withstand constant physical and chemical attacks. Stratified epithelium is named after the shape of the most apical layer of cells. Stratified squamous epithelium is the most common type found in the human body. In this tissue, the apical cells are squamous, whereas the basal layer contains either columnar or cuboidal cells. The basal cells divide to form new daughter cells, which gradually become...
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Cells of the Epidermis01:24

Cells of the Epidermis

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The epidermis is made of four or five layers of epithelial cells, depending on its location in the body. From deep to superficial, these layers are the stratum basale, stratum spinosum, stratum granulosum, stratum lucidum, and stratum corneum.
The cells in all these layers except the stratum basale are called keratinocytes, a type of cell that manufactures and stores the protein keratin. The keratinocytes in the stratum corneum are dead and regularly slough away, being replaced by cells from...
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Related Experiment Video

Updated: Oct 2, 2025

Cell Population Analyses During Skin Carcinogenesis
06:53

Cell Population Analyses During Skin Carcinogenesis

Published on: August 21, 2013

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Basal cell carcinoma: Histopathological gamut.

Preeti Sharma1, Vijay Wadhwan1, Vishal Bansal1

  • 1Department of Oral & Maxillofacial Pathology, Subharti Dental College & Hospital, Swami Vivekanand Subharti University, Meerut, Uttar Pradesh, India.

Indian Journal of Dental Research : Official Publication of Indian Society for Dental Research
|March 1, 2022
PubMed
Summary

This study presents two rare cases of basal cell carcinoma (BCC) with unusual histopathology. These pigmented BCCs mimicked other cancers, highlighting diagnostic challenges in cutaneous oncology.

Keywords:
Adenoid typebasal cell carcinomahistopathologypigmented

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Area of Science:

  • Dermatology
  • Oncology
  • Pathology

Background:

  • Basal cell carcinoma (BCC) is the most common skin cancer, typically found on sun-exposed facial areas.
  • Diagnosis is usually straightforward based on characteristic clinical and histopathological features.

Observation:

  • Two rare cases of BCC presented with diagnostic challenges due to atypical histopathology.
  • Both cases exhibited significant pigmentation.

Findings:

  • One case displayed a glandular and ductal pattern, resembling adenoid cystic carcinoma.
  • The histopathological variations in these BCCs underscore the importance of thorough evaluation.

Implications:

  • Recognizing rare histopathological variants of BCC is crucial for accurate diagnosis and treatment.
  • These cases expand the understanding of BCC's diverse presentations in dermatopathology.