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An Adoptive Transfer Model of Rheumatoid Arthritis in Mice
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Biologic therapy in relapsing polychondritis: navigating between options.

Roberto Padoan1, Debora Campaniello1, Luca Iorio1

  • 1Division of Rheumatology, Department of Medicine DIMED, University of Padova, Padova, Italy.

Expert Opinion on Biological Therapy
|March 1, 2022
PubMed
Summary
This summary is machine-generated.

Relapsing polychondritis (RP) treatment is challenging. Biologic therapies, particularly TNFα inhibitors, show promise for refractory cases after conventional treatments fail, but efficacy varies.

Keywords:
Relapsing polychondritisanakinraanti-tnfαbiologic therapybiological agentsinfliximabrituximabtocilizumab

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Area of Science:

  • Rheumatology
  • Immunology
  • Systemic Inflammatory Diseases

Background:

  • Relapsing polychondritis (RP) is a rare systemic inflammatory disorder affecting cartilage.
  • Clinical presentations of RP range from mild to life-threatening.
  • Current RP treatment relies heavily on clinical experience and case reports.

Purpose of the Study:

  • To review the current literature on biologic therapies for relapsing polychondritis.
  • To provide expert opinion on the efficacy and safety of different biologic agents in RP management.
  • To guide treatment strategies for challenging RP cases.

Main Methods:

  • Literature review of studies investigating biologics in RP.
  • Analysis of case reports and series detailing biologic use.
  • Expert opinion synthesis on treatment algorithms.

Main Results:

  • Glucocorticoids are the first-line treatment for RP.
  • Conventional immunosuppressants are used for refractory cases or steroid-sparing.
  • Biologics are considered after conventional treatment failure or for severe RP.

Conclusions:

  • TNFα inhibitors (infliximab, adalimumab) are preferred biologic agents for RP.
  • Abatacept and tocilizumab show efficacy as second-line biologics, with infection risks noted.
  • Anakinra, rituximab, and JAK inhibitors have limited or controversial data for RP treatment.