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Updated: Aug 14, 2026
08:48
Bio-energetics Investigation of Candida albicans Using Real-time Extracellular Flux Analysis
Published on: March 19, 2019
Abstract:
Most CNS fungal infections can be divided into those that occur in normal hosts and those that occur in the immunosuppressed host. Cryptococcal infection, however, is common in both groups. The usual clinical presentation of a CNS fungal infection is chronic headache and mental status change. The CSF shows a lymphocytic meningitis with low sugar and high protein. Amphotericin B remains the drug of choice for most CNS fungal infections.
Insights
Central nervous system (CNS) fungal infections present with chronic headache and mental status changes. Cryptococcal infections affect both normal and immunosuppressed hosts, with Amphotericin B being the primary treatment.
Area of Science:
- Neurology
- Infectious Diseases
- Mycology
Background:
- Central nervous system (CNS) fungal infections are a significant clinical challenge.
- Infections typically affect either normal or immunosuppressed hosts.
- Cryptococcal infections are notable for occurring in both host types.
Purpose of the Study:
- To outline the common clinical presentations and diagnostic findings of CNS fungal infections.
- To highlight Cryptococcus as a common pathogen across different host groups.
- To identify the primary therapeutic agent for these infections.
Main Methods:
- Review of clinical presentations of CNS fungal infections.
- Analysis of cerebrospinal fluid (CSF) findings.
- Evaluation of treatment guidelines for fungal meningitis.
Main Results:
- Common symptoms include chronic headache and altered mental status.
- CSF analysis often reveals lymphocytic meningitis with low glucose and high protein levels.
- Amphotericin B is identified as the drug of choice.
Conclusions:
- CNS fungal infections require prompt recognition and diagnosis.
- Cryptococcal infections represent a common and broad-spectrum challenge.
- Amphotericin B is the cornerstone of treatment for most CNS fungal infections.
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