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Nasal and systemic inflammation in Chronic Obstructive Pulmonary Disease (COPD)
Nicolai Obling1, Vibeke Backer2, John R Hurst3
1Department of Respiratory Medicine, Zealand University Hospital Næstved, Denmark; Institute for Regional Health Research, University of Southern, Denmark.
Respiratory Medicine
|March 2, 2022
Summary
Chronic Obstructive Pulmonary Disease (COPD) patients with significant upper airway symptoms show elevated inflammatory markers, specifically Interleukin-1 beta and Interleukin-3, in both nasal samples and serum. These findings highlight upper airway inflammation in COPD.
Area of Science:
- Immunology
- Pulmonology
- Otorhinolaryngology
Background:
- Systemic inflammation is characteristic of Chronic Obstructive Pulmonary Disease (COPD).
- Inflammation in the upper airways of COPD patients is less understood.
- Upper airway symptoms are common in COPD patients.
Purpose of the Study:
- To investigate the inflammatory profile in the upper airway and serum of COPD patients.
- To correlate upper airway inflammation with symptom severity and COPD burden.
Main Methods:
- 180 COPD patients were analyzed.
- Inflammatory profiles were measured using a 14-plex multiplex immunoassay in nasal and serum samples.
- Disease burden and upper airway symptoms were assessed using the CAT and SNOT22_nasal questionnaires, respectively.
Main Results:
- Patients with high upper airway symptoms (SNOT22_nasal ≥6) had significantly higher nasal levels of IL-1 beta and IL-3, and higher serum levels of IL-1 beta.
- Upper airway symptom scores correlated positively with nasal IL-3 and serum IL-1 beta levels.
- High upper airway symptoms in COPD were associated with eosinophilic and neutrophilic inflammation markers.
Conclusions:
- COPD patients with significant upper airway symptoms exhibit distinct inflammatory profiles in both the upper airway and systemic circulation.
- Elevated IL-1 beta and IL-3 levels are associated with increased upper airway symptom burden in COPD.
- Targeting upper airway inflammation may be beneficial for managing COPD symptoms.
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