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Updated: Oct 1, 2025

3D-Neuronavigation In Vivo Through a Patient's Brain During a Spontaneous Migraine Headache
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Cluster headache in adults.

Jason C Ray1,2,3,4, Richard J Stark1,2,3,4, Elspeth J Hutton1,2,3,4

  • 1Department of Neurology, Alfred Hospital.

Australian Prescriber
|March 2, 2022
PubMed
Summary
This summary is machine-generated.

Cluster headache involves severe, one-sided attacks with autonomic symptoms. Treatments include sumatriptan, oxygen, verapamil, and emerging therapies targeting calcitonin gene-related peptide.

Keywords:
calcitonin gene-related peptidecluster headachetrigeminal autonomic cephalalgiastriptans

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Area of Science:

  • Neurology
  • Headache Medicine

Background:

  • Cluster headache presents as severe, unilateral head pain with autonomic symptoms and restlessness.
  • Attacks occur frequently, lasting 15-180 minutes.

Purpose of the Study:

  • To summarize current understanding and treatment of cluster headache.
  • To highlight emerging therapies for cluster headache management.

Main Methods:

  • Review of existing literature on cluster headache diagnosis and treatment.
  • Analysis of first-line and emerging therapeutic options.

Main Results:

  • First-line acute treatments include sumatriptan and high-flow oxygen.
  • High-dose verapamil is the primary preventive therapy, requiring arrhythmia monitoring.
  • Neuromodulation shows potential benefit for some patients.

Conclusions:

  • Current management involves established acute and preventive treatments.
  • Emerging therapies, particularly those targeting calcitonin gene-related peptide, offer new hope for cluster headache patients.