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Rapid chemically selective 3D imaging in the mid-infrared
Eric O Potma1,2,3, David Knez1, Yong Chen4
1Department of Chemistry, University of California Irvine, California 92697, USA.
Optica
|March 2, 2022
Summary
Mid-infrared optical coherence tomography (MIR-OCT) can now image deeper. This new method uses two-photon absorption for high-speed, chemically selective imaging of materials and biological samples in seconds.
Area of Science:
- Optics and Photonics
- Biomedical Imaging
- Materials Science
Background:
- Mid-infrared optical coherence tomography (MIR-OCT) offers deeper penetration imaging due to reduced light scattering.
- Current MIR-OCT methods face limitations in image acquisition speed because of MIR detection challenges.
Purpose of the Study:
- To develop a high-speed MIR tomography technique.
- To overcome the slow imaging speed of conventional MIR-OCT.
Main Methods:
- Utilized femtosecond nondegenerate two-photon absorption of mid-infrared light.
- Employed a conventional silicon-based CCD camera for detection.
- Achieved wide-field, high-definition tomographic imaging.
Main Results:
- Demonstrated high-speed tomographic imaging in seconds.
- Enabled chemical selectivity in imaging.
- Successfully imaged structured materials and biological samples.
Conclusions:
- This novel approach significantly enhances MIR tomography speed.
- The technique provides chemical selectivity for diverse sample types.
- Opens new possibilities for rapid, in-depth material and biological analysis.
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