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Molecular Fluorescent Probes for Liver Tumor Imaging
Qian Liu1, Jia Huang1, Longwei He2
1Hunan Provincial Clinical Research Center for Metabolic Associated Fatty Liver Disease, Clinical Research Institute, the Affiliated Nanhua Hospital, Hengyang Medical School, University of South China, Hengyang, 421002, Hunan, P. R. China.
Chemistry, an Asian Journal
|March 2, 2022
Summary
Molecular fluorescent probes offer advanced imaging for liver cancer, improving surgical precision and reducing recurrence. This review highlights recent developments and future challenges for clinical applications.
Area of Science:
- Oncology
- Biomedical Engineering
- Molecular Imaging
Background:
- Liver cancer presents high morbidity and mortality, with traditional hepatectomy often resulting in incomplete resection due to difficulties in distinguishing tumor margins.
- Incomplete tumor resection leads to high rates of liver cancer recurrence, underscoring the need for improved diagnostic and surgical guidance.
Purpose of the Study:
- To review recent advancements in molecular fluorescent probes for liver cancer imaging and therapy.
- To discuss the potential challenges and future directions for the clinical application of these probes in liver tumor management.
Main Methods:
- Literature review of recent developments in always-on and activatable fluorescent probes.
- Analysis of the advantages of fluorescent probes, including non-invasiveness, high sensitivity, and real-time imaging capabilities.
Main Results:
- Molecular fluorescent probes show significant promise for enhancing the accuracy of liver cancer imaging.
- These probes facilitate real-time visualization, aiding in the precise identification of tumor boundaries during surgical procedures.
- Both always-on and activatable probe designs are being explored for improved diagnostic and therapeutic outcomes.
Conclusions:
- Molecular fluorescent probes represent a significant advancement over traditional methods for liver cancer diagnosis and treatment.
- Further development is needed to address potential challenges and fully realize the clinical potential of fluorescent probes in liver tumor imaging and therapy.
