[Studies on the mutagenicity test methods: comparison of the screening methods using Salmonella typhimurium and...

Twenty-two acridine compounds and eleven phenanthridinium derivatives were tested for the induction of mutation in both eukaryotic, Saccharomyces cerevisiae and bacterial, Salmonella typhimurium. Summarized and discussed about the relationships between mutagenic activity and chemical structure of their compounds. Some metal compounds were examined for the induction of mitotic crossing over, mitotic gene conversion and reversion in yeast. Furthermore, the effects of the cell growth at the presence of these metal compounds on the mutations induced by nitrous acid was also examined. Mutagenic susceptibility of the yeast to these metal compounds on the comparison to the bacteria and the mechanisms of metal mutagenicity were discussed.