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The Unfolded Protein Response at the Tumor-Immune Interface
Maurizio Zanetti1, Su Xian2, Magalie Dosset1
1The Laboratory of Immunology, Department of Medicine and Moores Cancer Center, University of California San Diego, La Jolla, CA, United States.
Frontiers in Immunology
|March 3, 2022
Summary
The unfolded protein response (UPR) links aneuploidy to immune cell dysfunction in cancer. Aneuploidy negatively impacts the tumor microenvironment and local immunity.
Area of Science:
- Oncology
- Immunology
- Cell Biology
Background:
- The tumor-immune interface is critical for cancer immunotherapy success.
- The unfolded protein response (UPR) influences tumor cell properties and immune cell function.
- Aneuploidy, or abnormal chromosome number, is linked to immune dysregulation in the tumor microenvironment.
Purpose of the Study:
- To review the role of the UPR in connecting aneuploidy with immune cell dysfunction.
- To discuss how aneuploidy impacts the tumor microenvironment (TME) and local immunity.
Main Methods:
- Literature review of studies on UPR, aneuploidy, and the tumor microenvironment.
- Synthesis of recent findings linking UPR, aneuploidy, and immune cell regulation.
Main Results:
- The UPR acts as a non-cell-autonomous mediator between aneuploidy and immune cell dysregulation.
- Aneuploidy is identified as a significant negative regulator of local anti-tumor immunity.
Conclusions:
- Aneuploidy and UPR interplay complicates the understanding of the TME.
- Aneuploidy's role in suppressing local immunity has significant implications for cancer immunotherapy.
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