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What Is the Therapeutic Reference Range for Levetiracetam? Grand Round/A Case Study
Sylvain Couderc1, Mondher Chouchane2, Franck Saint-Marcoux1
1Department of Pharmacology and Toxicology, CHU Limoges, Limoges; and.
Therapeutic Drug Monitoring
|March 3, 2022
Summary
The Arbeitsgemeinschaft für Neuropsychopharmakologie und Pharmakopsychiatrie guidelines suggest a levetiracetam therapeutic range of 10-40 mg/L. This study explores the potential for a wider levetiracetam interval in specific patient populations.
Area of Science:
- Pharmacology
- Clinical Pharmacy
- Neuroscience
Background:
- The Arbeitsgemeinschaft für Neuropsychopharmakologie und Pharmakopsychiatrie (ANNP) proposed a levetiracetam therapeutic drug monitoring (TDM) range of 10-40 mg/L in 2011.
- The ANNP 2017 guidelines experienced a revision, initially changing the levetiracetam range to 20-40 mg/L, then reverting to 10-40 mg/L via erratum.
Purpose of the Study:
- To evaluate the established therapeutic drug monitoring range for levetiracetam.
- To discuss the potential for a broadened therapeutic interval for levetiracetam in select patient groups.
Main Methods:
- Review of existing Therapeutic Drug Monitoring guidelines for levetiracetam.
- Discussion of clinical considerations for adjusting levetiracetam dosage ranges.
Main Results:
- The study authors concur with the 10-40 mg/L therapeutic range for levetiracetam.
- The research highlights the need to consider individualized patient factors when determining optimal levetiracetam levels.
Conclusions:
- The 10-40 mg/L range for levetiracetam is considered appropriate.
- Further investigation into wider therapeutic intervals for levetiracetam in specific patient populations is warranted.
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