[Action of fenitrothion (Agria 1050) on the development of a surgical infection with Corynebacterium pyogenes in...

Investigations were carried out on twelve Starozagorska breed sheep divided into two groups of 6 animals each. All sheep were treated with phenitrothion (Agria-50) at the rate of 300 mg per kg body mass, singly, by means of a stomach tube. At the first hour of treatment the sheep of the second group were injected with 3 cm3 broth culture of Corynebacterium pyogenes. The general condition, the manifestation of signs of toxicity, and some paraclinical indices were followed up. The animals of the first group exhibited symptoms of toxicity and changes in the paraclinical indices, which was characteristic of the weak form of the infection course. Those of the second group developed the disease at a rapid course, with affection of the general state, atony of the forestomach, substantial changes in the hemopoiesis, the enzyme activity, the glycogenesis process, and the blood picture (erythropenia, drop of the hemoglobin content, higher erythrocyte sedimentation rate, leukocytosis with neutrophilia, strong drop of plasmal and serum cholinesterase, hyperglycaemia). Results pointed to the fact that Agria-1050 intoxication aggravated the course of the supurative surgical infection.