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Mapping thalamic-anterior cingulate monosynaptic inputs in adult mice
Man Xue1, Wan-Tong Shi1, Si-Bo Zhou1
1Center for Neuron and Disease, Frontier Institutes of Science and Technology, Xi'an Jiaotong University, Xi'an, China.
This study maps direct thalamic inputs to the anterior cingulate cortex (ACC) in adult mice using advanced tracing. Findings reveal projections from multiple thalamic nuclei, clarifying ACC circuitry.
Area of Science:
- Neuroscience
- Anatomy
Background:
- The anterior cingulate cortex (ACC) is crucial for processing pain and emotion.
- Thalamocortical pathways form the primary sensory input to the ACC.
- Previous research on ACC-thalamus connections primarily used non-rodent models.
Purpose of the Study:
- To systematically map monosynaptic inputs from the thalamus to the ACC in adult mice.
- To provide detailed anatomical evidence for thalamo-ACC connectivity in a key model organism.
Main Methods:
- Utilized a rabies virus-based retrograde tracing system for precise input mapping.
- Employed high-throughput VISoR imaging for 3D whole-brain reconstruction, focusing on the thalamus.
Main Results:
- Identified direct projections from diverse thalamic sub-nuclei to the ACC.
- Confirmed inputs from anterior, ventral, medial, lateral, midline, and intralaminar thalamic nuclei.
Conclusions:
- Established key anatomical evidence for direct thalamo-ACC connections in adult mice.
- Provides a foundational map for studying ACC function and plasticity in mice.
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