Hysterosalpingography with Oil-Soluble Contrast Medium Does Not Increase Newborn Hypothyroidism

Area of Science:

• Reproductive endocrinology
• Neonatal screening
• Radiological procedures

Background:

• Hysterosalpingography with oil-soluble contrast medium (OSCM HSG) enhances fertility in idiopathic infertility.
• OSCM contains high iodine levels, raising concerns about potential fetal thyroid impact.
• The effect of preconceptional OSCM HSG on neonatal thyroid function requires investigation.

Purpose of the Study:

• To evaluate the impact of preconceptional OSCM HSG on neonatal thyroid function.
• To determine the incidence of congenital hypothyroidism following OSCM HSG.

Main Methods:

• Retrospective analysis of newborn thyroid-stimulating hormone (TSH) data.
• Cohort included neonates conceived within six months of OSCM HSG (2000-2019, Auckland).
• TSH levels assessed via routine newborn screening at 48-72 hours of life.

Main Results:

• 146 neonates were analyzed, all exhibiting normal TSH levels (1-7 mIU/L).
• Conception rates within 3 cycles post-OSCM HSG were 76%.
• No significant difference in TSH levels was observed between early and later conceptions.

Conclusions:

• Preconceptional OSCM HSG is not associated with an increased risk of congenital hypothyroidism.
• Neonatal thyroid function appears unaffected by prior OSCM HSG.
• The procedure is considered safe concerning fetal thyroid development in the studied population.