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Electro-mechanical Systems01:19

Electro-mechanical Systems

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Electromechanical systems are intricate configurations that effectively combine electrical and mechanical elements to achieve a desired outcome. Central to many of these systems is the DC motor, a device that converts electrical energy into mechanical motion, enabling various applications ranging from simple fans to complex robotic mechanisms.
A key component of the DC motor is the armature, a rotating circuit positioned within a magnetic field. As an electric current passes through the...
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Electrochemistry: Overview01:04

Electrochemistry: Overview

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Electrochemistry is the branch of chemistry that studies the relationship between electrical quantities and chemical reactions, particularly oxidation and reduction. Oxidation is the loss of electrons from a substance, whereas reduction refers to the gain of electrons. A substance with a strong electron affinity is called an oxidizing agent (oxidant), and a reducing agent (reductant) is a species that donates electrons. Oxidation and reduction processes are pivotal to electrochemical reactions,...
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Thermal and Photochemical Electrocyclic Reactions: Overview01:26

Thermal and Photochemical Electrocyclic Reactions: Overview

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Electrocyclic reactions are reversible reactions. They involve an intramolecular cyclization or ring-opening of a conjugated polyene. Shown below are two examples of electrocyclic reactions. In the first reaction, the formation of the cyclic product is favored. In contrast, in the second reaction, ring-opening is favored due to the high ring strain associated with cyclobutene formation.
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Cyclic Processes And Isolated Systems01:19

Cyclic Processes And Isolated Systems

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A thermodynamic system with zero heat exchange and work is an isolated system. For these systems, the internal energy remains constant.
In the case of a non-isolated system, the change in the internal energy is zero only if the process is cyclic. A thermodynamic process is considered cyclic if the system undergoes a series of changes and returns to its initial state. 
Consider a cyclic process that returns to its initial state, undergoing a four-step process. The heat transfer along each...
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Feedback control systems01:26

Feedback control systems

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Feedback control systems are categorized in various ways based on their design, analysis, and signal types.
Linear feedback systems are theoretical models that simplify analysis and design. These systems operate under the principle that their output is directly proportional to their input within certain ranges. For instance, an amplifier in a control system behaves linearly as long as the input signal remains within a specific range. However, most physical systems exhibit inherent nonlinearity...
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MOS Capacitor01:25

MOS Capacitor

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A Metal-Oxide-Semiconductor (MOS) capacitor is a fundamental structure used extensively in semiconductor device technology, particularly in the fabrication of integrated circuits and MOSFETs (metal-oxide-semiconductor field-effect transistors). The MOS capacitor consists of three layers: a metal gate, a dielectric oxide, and a semiconductor substrate.
The metal gate is typically made from highly conductive materials such as aluminum or polysilicon. Beneath the metal gate lies a thin layer of...
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Related Experiment Video

Updated: Oct 1, 2025

In Vitro Multiparametric Cellular Analysis by Micro Organic Charge-modulated Field-effect Transistor Arrays
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In Vitro Multiparametric Cellular Analysis by Micro Organic Charge-modulated Field-effect Transistor Arrays

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Cytomorphic Electronic Systems: A review and perspective.

Douglas Raymond Beahm1, Yijie Deng1, Tanner G Riley2

  • 1Thayer School of Engineering, Dartmouth College.

IEEE Nanotechnology Magazine
|March 4, 2022
PubMed
Summary
This summary is machine-generated.

Cytomorphic systems leverage common thermodynamic laws to simulate complex biochemical reactions efficiently. These systems offer a significant advantage over digital computers for systems biology simulations, enabling faster drug discovery and synthetic biology design.

Keywords:
COVID-19analog computingbiological design automationcytomorphicdrug discoverysupercomputersynthetic biologysystems biology

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Area of Science:

  • Biophysics
  • Computational Biology
  • Analog Computing

Background:

  • Stochastic biochemical reactions and transistor electron flux follow common Boltzmann-exponential thermodynamic laws.
  • Existing digital systems face limitations in simulating large-scale, complex, and nonlinear biological networks due to rapid scaling in simulation time.

Purpose of the Study:

  • To introduce and explore the application of cytomorphic systems for simulating stochastic biochemical reaction networks.
  • To highlight the advantages of cytomorphic systems over digital systems for systems biology and computational medicine.

Main Methods:

  • Mapping and simulating arbitrary stochastic biochemical reaction networks using cytomorphic systems built on subthreshold analog circuits.
  • Utilizing digitally programmable parameters and connectivity to compile complex biological networks onto cytomorphic hardware.

Main Results:

  • Cytomorphic systems accurately model noisy, nonlinear, asynchronous, stiff, and non-modular feedback dynamics in biological networks.
  • Simulation time for stochastic networks scales constantly with the number of reactions or molecules in cytomorphic systems, unlike digital systems.

Conclusions:

  • Cytomorphic systems offer a powerful new paradigm for large-scale systems biology simulations, enabling supercomputing capabilities for complex biological models.
  • Applications include rapid drug-cocktail formulation, cancer network simulation, synthetic biology circuit design, and advancing personalized medicine.