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Related Concept Videos

Site-Targeted Drug Delivery Systems: Polymeric Carriers01:24

Site-Targeted Drug Delivery Systems: Polymeric Carriers

138
Polymeric carriers enhance targeted drug delivery by increasing efficacy while minimizing off-target effects. These carriers comprise a biodegradable polymeric backbone integrated with functional elements that enable targeting, improve physicochemical properties, and regulate drug release.Targeting MechanismsThe targeting ability of polymeric carriers is mediated by a homing device, which is a molecular recognition component designed to selectively bind to specific tissues or cells. Monoclonal...
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Modified-Release Drug Delivery Systems: Site-Targeted01:24

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Site-targeted drug delivery systems enhance therapeutic efficacy while minimizing systemic toxicity and treatment costs. Unlike conventional methods, these systems ensure precise drug delivery, improving bioavailability and reducing side effects. Targeted drug delivery is classified into three levels. First-order targeting directs drugs to the capillary beds of specific organs or tissues. Second-order targets specific cell types, such as tumor cells, using receptor-mediated interactions.
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Modified-Release Drug Delivery Systems: Stimuli-Activated01:30

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Stimuli-activated drug delivery systems are designed to release drugs in response to specific physical, chemical, or biological stimuli. These systems often utilize hydrogels—three-dimensional, hydrophilic polymer networks capable of swelling in aqueous environments and retaining significant fluid volumes. Upon exposure to particular stimuli, these hydrogels undergo structural transitions that allow the embedded drug to be released. Due to this adaptive behavior, such systems are also...
153

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Updated: Apr 21, 2026

Manufacture and Drug Delivery Applications of Silk Nanoparticles
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Smart Ultrasound-Responsive Nanoparticles for Drug Delivery.

Yanqing Zhong1, Geoffrey P Luke1,2

  • 1Thayer School of Engineering at Dartmouth College, Hanover, NH 03755.

IEEE Nanotechnology Magazine
|April 20, 2026
PubMed
Summary
This summary is machine-generated.

Smart nanoparticles offer controlled drug delivery. Ultrasound can trigger these nanoparticles for precise, on-demand drug release in targeted tissues, minimizing side effects and advancing therapeutic strategies.

Keywords:
Ultrasoundnanotechnologysmart nanoparticlestriggered drug delivery

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Area of Science:

  • Nanotechnology
  • Biomedical Engineering
  • Pharmacology

Background:

  • Drug delivery systems aim to improve therapeutic efficacy and reduce side effects.
  • Nanoparticles offer a platform for encapsulating therapeutic molecules for controlled release.
  • Smart nanoparticles respond to external stimuli for targeted drug release.

Purpose of the Study:

  • To review recent advancements in smart nanoparticles for drug delivery.
  • To explore the potential of ultrasound as an external stimulus for triggering drug release.
  • To highlight strategies for real-time, on-demand drug delivery in situ.

Main Methods:

  • Review of current literature on smart nanoparticles and ultrasound-triggered drug release.
  • Analysis of ultrasound's physical mechanisms (pressure, heating, shear forces) for cargo release.
  • Identification of research gaps and future directions in ultrasound-mediated drug delivery.

Main Results:

  • Smart nanoparticles can be designed to release drugs in response to ultrasound.
  • Ultrasound provides safe, focused energy delivery for in situ activation.
  • Controlled release minimizes off-target effects and enhances therapeutic outcomes.

Conclusions:

  • Ultrasound-responsive smart nanoparticles represent a promising frontier in targeted drug delivery.
  • Further research is needed to optimize nanoparticle design and ultrasound parameters for clinical translation.
  • This technology holds potential for impactful, real-time, on-demand therapeutic strategies.