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Updated: Oct 1, 2025

Development of Compendium for Esophageal Squamous Cell Carcinoma
Published on: April 12, 2024
The Relationship between MACC1/c-Met/Cyclin D1 Axis Expression and Prognosis in ESCC
Yan Shi1,2, Meng-Yan Li1, Hui Wang1
1Department of Pathology, The First Affiliated Hospital, Xinjiang Medical University, Urumqi, Xinjiang, China.
Background:
Esophageal cancer is one of the most common malignant tumors of the digestive system, with high incidence and mortality.
Methods:
Immunohistochemical method was used to detect the expression of MACC1, c-Met, and cyclin D1 in ESCC and its adjacent tissues. Statistical analysis was done by SPSS 23.0.
Results:
The high expression of MACC1 and cyclin D1 was significantly correlated with tumor size. High c-Met expression was associated with patient ethnicity. MACC1 expression was positively correlated with both c-Met and cyclin D1. c-Met expression was also positively correlated with cyclin D1. Patients with high expression of MACC1 and c-Met had worse OS; patients with high c-Met expression also had worse PFS.
Conclusion:
MACC1, c-Met, and cyclin D1 proteins are closely related to the occurrence and development of esophageal squamous cell carcinoma. MACC1 may affect the prognosis of ESCC by regulating the expression of the c-Met/cyclin D1 axis.
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