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Role and Mechanism of PKC-δ for Cardiovascular Disease: Current Status and Perspective

Li-Na Miao1,2, Deng Pan1,2, Junhe Shi1

  • 1Xiyuan Hospital, China Academy of Chinese Medical Sciences, Beijing, China.

Frontiers in Cardiovascular Medicine
|March 4, 2022
PubMed

Insights

Protein kinase C delta (PKC-δ) is crucial in cardiovascular diseases. Its activation regulates myocardial injury, fibrosis, and conditions like atherosclerosis and heart failure, offering therapeutic insights.

Area of Science:

  • Biochemistry
  • Cardiovascular Biology
  • Molecular Medicine

Background:

  • Protein kinase C (PKC) is a key enzyme family involved in cellular signaling.
  • PKC-δ, a member of the novel PKC subfamily, has demonstrated significant roles in cellular processes.
  • Dysregulation of PKC-δ is implicated in various cardiovascular pathologies.

Purpose of the Study:

  • To review the structure and function of PKC-δ.
  • To summarize current research on PKC-δ activation mechanisms.
  • To elucidate the role of PKC-δ in cardiovascular diseases and suggest future research directions.

Main Methods:

  • Literature review of existing research on PKC-δ.
  • Analysis of studies focusing on PKC-δ activation pathways.
  • Synthesis of data on PKC-δ involvement in cardiovascular disease models.

Main Results:

  • PKC-δ activation is a critical regulator of myocardial ischemia/reperfusion (IRI) injury.
  • PKC-δ influences myocardial fibrosis and progression of cardiovascular diseases.
  • Expression and activity levels of PKC-δ are linked to atherosclerosis, hypertension, cardiac hypertrophy, and heart failure.

Conclusions:

  • PKC-δ plays a significant role in the pathogenesis of cardiovascular diseases.
  • Understanding PKC-δ activation mechanisms is vital for developing targeted therapies.
  • Further research into PKC-δ functions may uncover novel therapeutic strategies for cardiovascular conditions.
Keywords:
PKCPKC-δcardiovascular diseasekinasemechanism

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