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Ranizurel safety evaluation in real-world -(RaSER) study.
Ashish Sharma1, Jayshree Arunaprakash2, Atheeshwar Das3
1Lotus Eye Hospital and Institute, Avinashi Road, Coimbatore, TN, India.
American Journal of Ophthalmology Case Reports
|March 4, 2022
Summary
Ranizurel injections show promising early results in real-world clinical outcomes. This study found ranizurel to be a safe and effective treatment for various eye conditions, improving vision and reducing retinal thickness.
Area of Science:
- Ophthalmology
- Retinal Diseases
- Pharmacology
Background:
- Intravitreal injections are a common treatment for retinal diseases.
- Anti-VEGF agents are widely used, but alternatives are being explored.
- Ranizurel is a biologic agent for ophthalmic use.
Purpose of the Study:
- To evaluate the early clinical safety and efficacy of ranizurel in real-world settings.
- To assess outcomes in treatment-naive and previously treated patients.
Main Methods:
- Retrospective, multi-center study of 22 eyes treated with intravitreal ranizurel 0.5 mg.
- Data collected between January 2021 and April 2021.
- Evaluated best-corrected visual acuity (BCVA), central subfield thickness (CST), intraocular pressure (IOP), and adverse events.
Main Results:
- No ocular or systemic adverse events were reported.
- Significant improvement in mean BCVA from 0.48 to 0.26 LogMAR (p=0.001).
- Significant reduction in mean CST from 448.4 μm to 328.3 μm (p=0.001).
Conclusions:
- Ranizurel demonstrates favorable early safety and efficacy.
- It is a potential safe alternative biologic for retinal conditions.
- Real-world data supports ranizurel's use in both treatment-naive and previously treated patients.
Keywords:
Anti-VEGFBiosimilarCME, Cystoid macular edemaCRVO, Central retinal vein occlusionDME, Diabetic macular edemaEarly experienceIRF, Intra-retinal fluidNSD, Neurosensory detachmentRanizuRelReal worldSRF, Sub retinal fluidn-AMD, neovascular age related macular degenerationMore Related Videos
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